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Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV. Sajan MP, et al. Among authors: kahn cr. Neurobiol Aging. 2018 Jan;61:225-237. doi: 10.1016/j.neurobiolaging.2017.09.001. Epub 2017 Sep 15. Neurobiol Aging. 2018. PMID: 29032894 Free PMC article.
Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.
Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV. Sajan MP, et al. Among authors: kahn cr. Diabetologia. 2009 Jun;52(6):1197-207. doi: 10.1007/s00125-009-1336-5. Epub 2009 Apr 9. Diabetologia. 2009. PMID: 19357831 Free PMC article.
Retraction: Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of β1-Integrin and Phosphatidylinositol 3'-Kinase/AKT Signaling.
Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, Richardson P, Munshi NC, Kahn CR, Mitsiades C, Anderson KC. Tai YT, et al. Among authors: kahn cr. Cancer Res. 2024 Mar 15;84(6):938. doi: 10.1158/0008-5472.CAN-24-0519. Cancer Res. 2024. PMID: 38486484 No abstract available.
PPARγ agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells.
Chen Z, Ghavimi SAA, Wu M, McNamara J, Barreiro O, Maridas D, Kratchmarov R, Siegel A, Djeddi S, Gutierrez-Arcelus M, Brennan PJ, Padera TP, von Andrian U, Mehrara B, Greene AK, Kahn CR, Orgill DP, Sinha I, Rosen V, Agarwal S. Chen Z, et al. Among authors: kahn cr. JCI Insight. 2023 Dec 22;8(24):e165324. doi: 10.1172/jci.insight.165324. JCI Insight. 2023. PMID: 38131378 Free PMC article.
Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Among authors: kahn cr. Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. Epub 2023 May 23. Metabolism. 2023. PMID: 37230214
809 results