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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Sarkar S, et al. Among authors: panicker n. NPJ Parkinsons Dis. 2017 Oct 17;3:30. doi: 10.1038/s41531-017-0032-2. eCollection 2017. NPJ Parkinsons Dis. 2017. PMID: 29057315 Free PMC article.
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.
Jin H, Kanthasamy A, Harischandra DS, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy AG. Jin H, et al. Among authors: panicker n. J Biol Chem. 2014 Dec 12;289(50):34743-67. doi: 10.1074/jbc.M114.576702. Epub 2014 Oct 23. J Biol Chem. 2014. PMID: 25342743 Free PMC article.
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.
Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A. Gordon R, et al. Among authors: panicker n. Neurobiol Dis. 2016 Sep;93:96-114. doi: 10.1016/j.nbd.2016.04.008. Epub 2016 May 2. Neurobiol Dis. 2016. PMID: 27151770 Free PMC article.
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A. Panicker N, et al. J Exp Med. 2019 Jun 3;216(6):1411-1430. doi: 10.1084/jem.20182191. Epub 2019 Apr 29. J Exp Med. 2019. PMID: 31036561 Free PMC article.
Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease.
Panicker N, Kanthasamy A, Kanthasamy AG. Panicker N, et al. Aging (Albany NY). 2019 Aug 27;11(16):5871-5873. doi: 10.18632/aging.102210. Epub 2019 Aug 27. Aging (Albany NY). 2019. PMID: 31454793 Free PMC article. No abstract available.
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, Ay M, Charli A, Harischandra D, Jin LW, Jin H, Rangaraju S, Anantharam V, Wulff H, Kanthasamy AG. Sarkar S, et al. Among authors: panicker n. J Clin Invest. 2020 Aug 3;130(8):4195-4212. doi: 10.1172/JCI136174. J Clin Invest. 2020. PMID: 32597830 Free PMC article.
69 results