Merino EF - Search Results

1

Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs.

Ghavami M, Merino EF, Yao ZK, Elahi R, Simpson ME, Fernández-Murga ML, Butler JH, Casasanta MA, Krai PM, Totrov MM, Slade DJ, Carlier PR, Cassera MB. Ghavami M, et al. Among authors: merino ef. ACS Infect Dis. 2018 Apr 13;4(4):549-559. doi: 10.1021/acsinfecdis.7b00159. Epub 2017 Nov 7. ACS Infect Dis. 2018. PMID: 29072835 Free PMC article.

2

The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.

Cassera MB, Gozzo FC, D'Alexandri FL, Merino EF, del Portillo HA, Peres VJ, Almeida IC, Eberlin MN, Wunderlich G, Wiesner J, Jomaa H, Kimura EA, Katzin AM. Cassera MB, et al. Among authors: merino ef. J Biol Chem. 2004 Dec 10;279(50):51749-59. doi: 10.1074/jbc.M408360200. Epub 2004 Sep 27. J Biol Chem. 2004. PMID: 15452112 Free article.

3

Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum.

Cassera MB, Merino EF, Peres VJ, Kimura EA, Wunderlich G, Katzin AM. Cassera MB, et al. Among authors: merino ef. Mem Inst Oswaldo Cruz. 2007 Jun;102(3):377-83. doi: 10.1590/s0074-02762007000300019. Mem Inst Oswaldo Cruz. 2007. PMID: 17568945 Free article.

4

Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum.

Cassera MB, Hazleton KZ, Riegelhaupt PM, Merino EF, Luo M, Akabas MH, Schramm VL. Cassera MB, et al. Among authors: merino ef. J Biol Chem. 2008 Nov 21;283(47):32889-99. doi: 10.1074/jbc.M804497200. Epub 2008 Sep 17. J Biol Chem. 2008. PMID: 18799466 Free PMC article.

5

A high-affinity adenosine kinase from Anopheles gambiae.

Cassera MB, Ho MC, Merino EF, Burgos ES, Rinaldo-Matthis A, Almo SC, Schramm VL. Cassera MB, et al. Among authors: merino ef. Biochemistry. 2011 Mar 22;50(11):1885-93. doi: 10.1021/bi101921w. Epub 2011 Feb 15. Biochemistry. 2011. PMID: 21247194 Free PMC article.

6

Transition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine.

Silva RG, Vetticatt MJ, Merino EF, Cassera MB, Schramm VL. Silva RG, et al. Among authors: merino ef. J Am Chem Soc. 2011 Jun 29;133(25):9923-31. doi: 10.1021/ja2031294. Epub 2011 Jun 3. J Am Chem Soc. 2011. PMID: 21599004 Free PMC article.

7

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model.

Cassera MB, Hazleton KZ, Merino EF, Obaldia N 3rd, Ho MC, Murkin AS, DePinto R, Gutierrez JA, Almo SC, Evans GB, Babu YS, Schramm VL. Cassera MB, et al. Among authors: merino ef. PLoS One. 2011;6(11):e26916. doi: 10.1371/journal.pone.0026916. Epub 2011 Nov 11. PLoS One. 2011. PMID: 22096507 Free PMC article.

8

Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity.

Frame IJ, Merino EF, Schramm VL, Cassera MB, Akabas MH. Frame IJ, et al. Among authors: merino ef. Biochem J. 2012 Sep 1;446(2):179-90. doi: 10.1042/BJ20112220. Biochem J. 2012. PMID: 22670848 Free PMC article.

9

Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

Hazleton KZ, Ho MC, Cassera MB, Clinch K, Crump DR, Rosario I Jr, Merino EF, Almo SC, Tyler PC, Schramm VL. Hazleton KZ, et al. Among authors: merino ef. Chem Biol. 2012 Jun 22;19(6):721-30. doi: 10.1016/j.chembiol.2012.04.012. Chem Biol. 2012. PMID: 22726686 Free PMC article.

10

Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.

Bowman JD, Merino EF, Brooks CF, Striepen B, Carlier PR, Cassera MB. Bowman JD, et al. Among authors: merino ef. Antimicrob Agents Chemother. 2014;58(2):811-9. doi: 10.1128/AAC.01500-13. Epub 2013 Nov 18. Antimicrob Agents Chemother. 2014. PMID: 24247137 Free PMC article.

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