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New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut.
Qiang X, Liotta AS, Shiloach J, Gutierrez JC, Wang H, Ochani M, Ochani K, Yang H, Rabin A, LeRoith D, Lesniak MA, Böhm M, Maaser C, Kannengiesser K, Donowitz M, Rabizadeh S, Czura CJ, Tracey KJ, Westlake M, Zarfeshani A, Mehdi SF, Danoff A, Ge X, Sanyal S, Schwartz GJ, Roth J. Qiang X, et al. Among authors: ochani m, ochani k. NPJ Biofilms Microbiomes. 2017 Nov 13;3:31. doi: 10.1038/s41522-017-0039-9. eCollection 2017. NPJ Biofilms Microbiomes. 2017. PMID: 29152323 Free PMC article.
ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.
Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ. Al-Abed Y, et al. Among authors: ochani m, ochani k. J Biol Chem. 2005 Nov 4;280(44):36541-4. doi: 10.1074/jbc.C500243200. Epub 2005 Aug 22. J Biol Chem. 2005. PMID: 16115897 Free article.
Role of HMGB1 in apoptosis-mediated sepsis lethality.
Qin S, Wang H, Yuan R, Li H, Ochani M, Ochani K, Rosas-Ballina M, Czura CJ, Huston JM, Miller E, Lin X, Sherry B, Kumar A, Larosa G, Newman W, Tracey KJ, Yang H. Qin S, et al. Among authors: ochani m, ochani k. J Exp Med. 2006 Jul 10;203(7):1637-42. doi: 10.1084/jem.20052203. Epub 2006 Jul 3. J Exp Med. 2006. PMID: 16818669 Free PMC article.
Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis.
Huston JM, Gallowitsch-Puerta M, Ochani M, Ochani K, Yuan R, Rosas-Ballina M, Ashok M, Goldstein RS, Chavan S, Pavlov VA, Metz CN, Yang H, Czura CJ, Wang H, Tracey KJ. Huston JM, et al. Among authors: ochani m, ochani k. Crit Care Med. 2007 Dec;35(12):2762-8. doi: 10.1097/01.CCM.0000288102.15975.BA. Crit Care Med. 2007. PMID: 17901837
Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling.
Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M, Ochani M, Ochani K, Yang LH, Hudson L, Lin X, Patel N, Johnson SM, Chavan S, Goldstein RS, Czura CJ, Miller EJ, Al-Abed Y, Tracey KJ, Pavlov VA. Parrish WR, et al. Among authors: ochani m, ochani k. Mol Med. 2008 Sep-Oct;14(9-10):567-74. doi: 10.2119/2008-00079.Parrish. Mol Med. 2008. PMID: 18584048 Free PMC article.
29 results