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Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.
Mol Metab. 2018 Jan;7:23-34. doi: 10.1016/j.molmet.2017.11.002. Epub 2017 Nov 7.
Mol Metab. 2018.
PMID: 29153923
Free PMC article.
Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue.
Serbulea V, Upchurch CM, Schappe MS, Voigt P, DeWeese DE, Desai BN, Meher AK, Leitinger N.
Serbulea V, et al. Among authors: deweese de.
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6254-E6263. doi: 10.1073/pnas.1800544115. Epub 2018 Jun 11.
Proc Natl Acad Sci U S A. 2018.
PMID: 29891687
Free PMC article.
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The effect of oxidized phospholipids on phenotypic polarization and function of macrophages.
Serbulea V, DeWeese D, Leitinger N.
Serbulea V, et al.
Free Radic Biol Med. 2017 Oct;111:156-168. doi: 10.1016/j.freeradbiomed.2017.02.035. Epub 2017 Feb 21.
Free Radic Biol Med. 2017.
PMID: 28232205
Free PMC article.
Review.
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Nuclear Resonance Vibrational Spectroscopy Definition of Peroxy Intermediates in Catechol Dioxygenases: Factors that Determine Extra- versus Intradiol Cleavage.
Babicz JT Jr, Rogers MS, DeWeese DE, Sutherlin KD, Banerjee R, Böttger LH, Yoda Y, Nagasawa N, Saito M, Kitao S, Kurokuzu M, Kobayashi Y, Tamasaku K, Seto M, Lipscomb JD, Solomon EI.
Babicz JT Jr, et al. Among authors: deweese de.
J Am Chem Soc. 2023 Jul 19;145(28):15230-15250. doi: 10.1021/jacs.3c02242. Epub 2023 Jul 6.
J Am Chem Soc. 2023.
PMID: 37414058
Free PMC article.
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Nuclear Resonance Vibrational Spectroscopic Definition of the Fe(IV)2 Intermediate Q in Methane Monooxygenase and Its Reactivity.
Jacobs AB, Banerjee R, Deweese DE, Braun A, Babicz JT Jr, Gee LB, Sutherlin KD, Böttger LH, Yoda Y, Saito M, Kitao S, Kobayashi Y, Seto M, Tamasaku K, Lipscomb JD, Park K, Solomon EI.
Jacobs AB, et al. Among authors: deweese de.
J Am Chem Soc. 2021 Oct 6;143(39):16007-16029. doi: 10.1021/jacs.1c05436. Epub 2021 Sep 27.
J Am Chem Soc. 2021.
PMID: 34570980
Free PMC article.
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Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes.
Solomon EI, DeWeese DE, Babicz JT Jr.
Solomon EI, et al. Among authors: deweese de.
Biochemistry. 2021 Nov 23;60(46):3497-3506. doi: 10.1021/acs.biochem.1c00370. Epub 2021 Jul 15.
Biochemistry. 2021.
PMID: 34266238
Free PMC article.
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