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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem. 2018 Feb 8;61(3):650-665. doi: 10.1021/acs.jmedchem.7b01375. Epub 2017 Dec 27.
J Med Chem. 2018.
PMID: 29211475
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
Quinlan CL, Kaiser SE, Bolaños B, Nowlin D, Grantner R, Karlicek-Bryant S, Feng JL, Jenkinson S, Freeman-Cook K, Dann SG, Wang X, Wells PA, Fantin VR, Stewart AE, Grant SK.
Quinlan CL, et al. Among authors: grantner r.
Nat Chem Biol. 2017 Jul;13(7):785-792. doi: 10.1038/nchembio.2384. Epub 2017 May 29.
Nat Chem Biol. 2017.
PMID: 28553945
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Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.
Chang Q, Berdyshev E, Cao D, Bogaard JD, White JJ, Chen S, Shah R, Mu W, Grantner R, Bettis S, Grassi MA.
Chang Q, et al. Among authors: grantner r.
J Biol Chem. 2014 Mar 21;289(12):8337-52. doi: 10.1074/jbc.M113.507152. Epub 2014 Feb 11.
J Biol Chem. 2014.
PMID: 24519941
Free PMC article.
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Étude de validation du concept iCope : intervention téléphonique de psychoéducation menée par des infirmières auprès de patientes suivies dans un centre de diagnostic rapide à cause d’une anomalie au sein.
Maheu C, Singh M, Courbasson C, Sarvanantham S, Lambert S, Dubois S, Charbonneau A, Grantner R, Baku L, McCready D, Zanchetta M, Tock WL, Hébert M, Howell D.
Maheu C, et al. Among authors: grantner r.
Can Oncol Nurs J. 2023 Jan 1;33(1):108-115. doi: 10.5737/23688076331108. eCollection 2023 Winter.
Can Oncol Nurs J. 2023.
PMID: 36789216
Free PMC article.
French.
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A proof-of-concept study of iCope: A nurse-led psychoeducational telephone intervention for women attending a rapid diagnostic centre for breast abnormality.
Maheu C, Singh M, Courbasson C, Sarvanantham S, Lambert S, Dubois S, Charbonneau A, Grantner R, Baku L, McCready D, Zanchetta M, Tock WL, Hébert M, Howell D.
Maheu C, et al. Among authors: grantner r.
Can Oncol Nurs J. 2023 Jan 1;33(1):101-107. doi: 10.5737/23688076331101. eCollection 2023 Winter.
Can Oncol Nurs J. 2023.
PMID: 36789212
Free PMC article.
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