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Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
Veerman J, van den Bergh T, Orrling KM, Jansen C, Cos P, Maes L, Chatelain E, Ioset JR, Edink EE, Tenor H, Seebeck T, de Esch I, Leurs R, Sterk GJ. Veerman J, et al. Among authors: ioset jr. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81. doi: 10.1016/j.bmc.2016.02.032. Epub 2016 Feb 26. Bioorg Med Chem. 2016. PMID: 26935942
Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19.
Assmus F, Driouich JS, Abdelnabi R, Vangeel L, Touret F, Adehin A, Chotsiri P, Cochin M, Foo CS, Jochmans D, Kim S, Luciani L, Moureau G, Park S, Pétit PR, Shum D, Wattanakul T, Weynand B, Fraisse L, Ioset JR, Mowbray CE, Owen A, Hoglund RM, Tarning J, Lamballerie X, Nougairède A, Neyts J, Sjö P, Escudié F, Scandale I, Chatelain E. Assmus F, et al. Among authors: ioset jr. Microorganisms. 2022 Aug 12;10(8):1639. doi: 10.3390/microorganisms10081639. Microorganisms. 2022. PMID: 36014057 Free PMC article.
Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.
Keenan M, Alexander PW, Chaplin JH, Abbott MJ, Diao H, Wang Z, Best WM, Perez CJ, Cornwall SM, Keatley SK, Thompson RC, Charman SA, White KL, Ryan E, Chen G, Ioset JR, von Geldern TW, Chatelain E. Keenan M, et al. Among authors: ioset jr. Future Med Chem. 2013 Oct;5(15):1733-52. doi: 10.4155/fmc.13.139. Future Med Chem. 2013. PMID: 24144410 Free article.
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents.
Papadopoulou MV, Bloomer WD, Lepesheva GI, Rosenzweig HS, Kaiser M, Aguilera-Venegas B, Wilkinson SR, Chatelain E, Ioset JR. Papadopoulou MV, et al. Among authors: ioset jr. J Med Chem. 2015 Feb 12;58(3):1307-19. doi: 10.1021/jm5015742. Epub 2015 Jan 23. J Med Chem. 2015. PMID: 25580906 Free PMC article.
47 results