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Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis.
Enríquez-Cortina C, Bello-Monroy O, Rosales-Cruz P, Souza V, Miranda RU, Toledo-Pérez R, Luna-López A, Simoni-Nieves A, Hernández-Pando R, Gutiérrez-Ruiz MC, Calvisi DF, Marquardt JU, Bucio L, Gomez-Quiroz LE. Enríquez-Cortina C, et al. Among authors: marquardt ju. Oncotarget. 2017 Oct 24;8(61):104136-104148. doi: 10.18632/oncotarget.22024. eCollection 2017 Nov 28. Oncotarget. 2017. PMID: 29262627 Free PMC article.
Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.
Gomez-Quiroz LE, Seo D, Lee YH, Kitade M, Gaiser T, Gillen M, Lee SB, Gutierrez-Ruiz MC, Conner EA, Factor VM, Thorgeirsson SS, Marquardt JU. Gomez-Quiroz LE, et al. Among authors: marquardt ju. Toxicology. 2016 Jun 15;361-362:39-48. doi: 10.1016/j.tox.2016.07.004. Epub 2016 Jul 6. Toxicology. 2016. PMID: 27394961 Free PMC article.
Recombinant human hepatocyte growth factor provides protective effects in cerulein-induced acute pancreatitis in mice.
Palestino-Dominguez M, Pelaez-Luna M, Lazzarini-Lechuga R, Rodriguez-Ochoa I, Souza V, Miranda RU, Perez-Aguilar B, Bucio L, Marquardt JU, Gomez-Quiroz LE, Gutierrez-Ruiz MC. Palestino-Dominguez M, et al. Among authors: marquardt ju. J Cell Physiol. 2018 Dec;233(12):9354-9364. doi: 10.1002/jcp.26444. Epub 2018 Jun 19. J Cell Physiol. 2018. PMID: 29341114
Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.
Vollmar J, Lautem A, Closs E, Schuppan D, Kim YO, Grimm D, Marquardt JU, Fuchs P, Straub BK, Schad A, Gründemann D, Schattenberg JM, Gehrke N, Wörns MA, Baumgart J, Galle PR, Zimmermann T. Vollmar J, et al. Among authors: marquardt ju. Oncotarget. 2017 Dec 18;8(70):115667-115680. doi: 10.18632/oncotarget.23372. eCollection 2017 Dec 29. Oncotarget. 2017. PMID: 29383190 Free PMC article.
Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis.
Domínguez-Pérez M, Simoni-Nieves A, Rosales P, Nuño-Lámbarri N, Rosas-Lemus M, Souza V, Miranda RU, Bucio L, Uribe Carvajal S, Marquardt JU, Seo D, Gomez-Quiroz LE, Gutiérrez-Ruiz MC. Domínguez-Pérez M, et al. Among authors: marquardt ju. J Cell Physiol. 2019 May;234(5):7213-7223. doi: 10.1002/jcp.27474. Epub 2018 Sep 21. J Cell Physiol. 2019. PMID: 30239004
Ginkgo biloba induces different gene expression signatures and oncogenic pathways in malignant and non-malignant cells of the liver.
Czauderna C, Palestino-Dominguez M, Castven D, Becker D, Zanon-Rodriguez L, Hajduk J, Mahn FL, Herr M, Strand D, Strand S, Heilmann-Heimbach S, Gomez-Quiroz LE, Wörns MA, Galle PR, Marquardt JU. Czauderna C, et al. Among authors: marquardt ju. PLoS One. 2018 Dec 21;13(12):e0209067. doi: 10.1371/journal.pone.0209067. eCollection 2018. PLoS One. 2018. PMID: 30576355 Free PMC article.
GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion.
Gerardo-Ramírez M, Lazzarini-Lechuga R, Hernández-Rizo S, Jiménez-Salazar JE, Simoni-Nieves A, García-Ruiz C, Fernández-Checa JC, Marquardt JU, Coulouarn C, Gutiérrez-Ruiz MC, Pérez-Aguilar B, Gomez-Quiroz LE. Gerardo-Ramírez M, et al. Among authors: marquardt ju. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1540-1554. doi: 10.1016/j.bbadis.2019.03.003. Epub 2019 Mar 16. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30890427 Free article.
192 results