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Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade.
Sci Transl Med. 2018 Jan 3;10(422):eaam7577. doi: 10.1126/scitranslmed.aam7577.
Sci Transl Med. 2018.
PMID: 29298869
Free PMC article.
Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients.
Adair RA, Roulstone V, Scott KJ, Morgan R, Nuovo GJ, Fuller M, Beirne D, West EJ, Jennings VA, Rose A, Kyula J, Fraser S, Dave R, Anthoney DA, Merrick A, Prestwich R, Aldouri A, Donnelly O, Pandha H, Coffey M, Selby P, Vile R, Toogood G, Harrington K, Melcher AA.
Adair RA, et al. Among authors: beirne d.
Sci Transl Med. 2012 Jun 13;4(138):138ra77. doi: 10.1126/scitranslmed.3003578.
Sci Transl Med. 2012.
PMID: 22700953
Free PMC article.
Clinical Trial.
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Two-stage phase I dose-escalation study of intratumoral reovirus type 3 dearing and palliative radiotherapy in patients with advanced cancers.
Harrington KJ, Karapanagiotou EM, Roulstone V, Twigger KR, White CL, Vidal L, Beirne D, Prestwich R, Newbold K, Ahmed M, Thway K, Nutting CM, Coffey M, Harris D, Vile RG, Pandha HS, Debono JS, Melcher AA.
Harrington KJ, et al.
Clin Cancer Res. 2010 Jun 1;16(11):3067-77. doi: 10.1158/1078-0432.CCR-10-0054. Epub 2010 May 18.
Clin Cancer Res. 2010.
PMID: 20484020
Free PMC article.
Clinical Trial.
Item in Clipboard
Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery.
West E, Morgan R, Scott K, Merrick A, Lubenko A, Pawson D, Selby P, Hatfield P, Prestwich R, Fraser S, Eves D, Anthoney A, Twelves C, Beirne D, Patel P, O'Donnell D, Watt S, Waller M, Dietz A, Robinson P, Melcher A.
West E, et al.
J Immunother. 2009 Jan;32(1):66-78. doi: 10.1097/CJI.0b013e31818be071.
J Immunother. 2009.
PMID: 19307995
Item in Clipboard
An evaluation of a preparation of Mycobacterium vaccae (SRL172) as an immunotherapeutic agent in renal cancer.
Patel PM, Sim S, O'Donnell DO, Protheroe A, Beirne D, Stanley A, Tourani JM, Khayat D, Hancock B, Vasey P, Dalgleish A, Johnston C, Banks RE, Selby PJ.
Patel PM, et al.
Eur J Cancer. 2008 Jan;44(2):216-23. doi: 10.1016/j.ejca.2007.11.003.
Eur J Cancer. 2008.
PMID: 18164612
Clinical Trial.
Item in Clipboard
Randomized phase II study comparing thalidomide with medroxyprogesterone acetate in patients with metastatic renal cell carcinoma.
Lee CP, Patel PM, Selby PJ, Hancock BW, Mak I, Pyle L, James MG, Beirne DA, Steeds S, A'Hern R, Gore ME, Eisen T.
Lee CP, et al. Among authors: beirne da.
J Clin Oncol. 2006 Feb 20;24(6):898-903. doi: 10.1200/JCO.2005.03.7309.
J Clin Oncol. 2006.
PMID: 16484699
Clinical Trial.
Item in Clipboard
A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma.
Larkin JM, Hughes SA, Beirne DA, Patel PM, Gibbens IM, Bate SC, Thomas K, Eisen TG, Gore ME.
Larkin JM, et al. Among authors: beirne da.
Br J Cancer. 2007 Jan 15;96(1):44-8. doi: 10.1038/sj.bjc.6603503. Epub 2006 Dec 5.
Br J Cancer. 2007.
PMID: 17146474
Free PMC article.
Clinical Trial.
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A force for progress.
Beirne D.
Beirne D.
Nurs Stand. 2015 Mar 25;29(30):63. doi: 10.7748/ns.29.30.63.s45.
Nurs Stand. 2015.
PMID: 25804181
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