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Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.
Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Miyake K, Kiyuna T, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM. Kawaguchi K, et al. Among authors: hoffman rm. Oncotarget. 2017 Dec 12;9(1):915-923. doi: 10.18632/oncotarget.23185. eCollection 2018 Jan 2. Oncotarget. 2017. PMID: 29416666 Free PMC article.
IL-2 gene therapy of advanced lung cancer patients.
Tan Y, Xu M, Wang W, Zhang F, Li D, Xu X, Gu J, Hoffman RM. Tan Y, et al. Among authors: hoffman rm. Anticancer Res. 1996 Jul-Aug;16(4A):1993-8. Anticancer Res. 1996. PMID: 8712732 Clinical Trial.
Anticancer efficacy of methioninase in vivo.
Tan Y, Xu M, Guo H, Sun X, Kubota T, Hoffman RM. Tan Y, et al. Among authors: hoffman rm. Anticancer Res. 1996 Nov-Dec;16(6C):3931-6. Anticancer Res. 1996. PMID: 9042315
1,474 results