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A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase.
Ruan J, Liang D, Yan W, Zhong Y, Talley DC, Rai G, Tao D, LeClair CA, Simeonov A, Zhang Y, Chen F, Quinney NL, Boyles SE, Cholon DM, Gentzsch M, Henderson MJ, Xue F, Fang S. Ruan J, et al. Among authors: liang d. Mol Biol Cell. 2022 Nov 1;33(13):ar120. doi: 10.1091/mbc.E22-06-0233. Epub 2022 Sep 8. Mol Biol Cell. 2022. PMID: 36074076 Free PMC article.
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
Cardenas MG, Yu W, Beguelin W, Teater MR, Geng H, Goldstein RL, Oswald E, Hatzi K, Yang SN, Cohen J, Shaknovich R, Vanommeslaeghe K, Cheng H, Liang D, Cho HJ, Abbott J, Tam W, Du W, Leonard JP, Elemento O, Cerchietti L, Cierpicki T, Xue F, MacKerell AD Jr, Melnick AM. Cardenas MG, et al. Among authors: liang d. J Clin Invest. 2016 Sep 1;126(9):3351-62. doi: 10.1172/JCI85795. Epub 2016 Aug 2. J Clin Invest. 2016. PMID: 27482887 Free PMC article.
Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment.
Stern S, Liang D, Li L, Kurian R, Lynch C, Sakamuru S, Heyward S, Zhang J, Kareem KA, Chun YW, Huang R, Xia M, Hong CC, Xue F, Wang H. Stern S, et al. Among authors: liang d. JCI Insight. 2022 Jun 22;7(12):e153868. doi: 10.1172/jci.insight.153868. JCI Insight. 2022. PMID: 35579950 Free PMC article.
4,855 results