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The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development.
Goel S, Cohen M, Cömezoglu SN, Perrin L, André F, Jayabalan D, Iacono L, Comprelli A, Ly VT, Zhang D, Xu C, Humphreys WG, McDaid H, Goldberg G, Horwitz SB, Mani S. Goel S, et al. Among authors: iacono l. Clin Cancer Res. 2008 May 1;14(9):2701-9. doi: 10.1158/1078-0432.CCR-07-4151. Clin Cancer Res. 2008. PMID: 18451235 Clinical Trial.
Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra) in human plasma: method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degradants.
Xu XS, Zeng J, Mylott W, Arnold M, Waltrip J, Iacono L, Mariannino T, Stouffer B. Xu XS, et al. Among authors: iacono l. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 15;878(5-6):525-37. doi: 10.1016/j.jchromb.2009.12.014. Epub 2009 Dec 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20083444
A validated enantioselective LC-MS/MS assay for quantification of a major chiral metabolite of an achiral 11-β-hydroxysteroid-dehydrogenase 1 inhibitor in human plasma: Application to a clinical pharmacokinetic study.
Furlong MT, Ji QC, Iacono L, Dang O, Noren M, Bruce J, Aubry AF, Arnold ME. Furlong MT, et al. Among authors: iacono l. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:167-172. doi: 10.1016/j.jchromb.2016.03.043. Epub 2016 Mar 29. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27100678
Phase I and pharmacokinetic study of CT-322 (BMS-844203), a targeted Adnectin inhibitor of VEGFR-2 based on a domain of human fibronectin.
Tolcher AW, Sweeney CJ, Papadopoulos K, Patnaik A, Chiorean EG, Mita AC, Sankhala K, Furfine E, Gokemeijer J, Iacono L, Eaton C, Silver BA, Mita M. Tolcher AW, et al. Among authors: iacono l. Clin Cancer Res. 2011 Jan 15;17(2):363-71. doi: 10.1158/1078-0432.CCR-10-1411. Epub 2011 Jan 11. Clin Cancer Res. 2011. PMID: 21224368 Clinical Trial.
A phase I study of oral ixabepilone in patients with advanced solid tumors.
Deeken JF, Marshall JL, Pishvaian MJ, Hwang J, Ahlers CM, Clemens PL, Parker SM, Iacono L, LoRusso PM. Deeken JF, et al. Among authors: iacono l. Cancer Chemother Pharmacol. 2014 May;73(5):1071-8. doi: 10.1007/s00280-014-2443-7. Epub 2014 Mar 25. Cancer Chemother Pharmacol. 2014. PMID: 24663504 Clinical Trial.
85 results