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Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia.
ChemMedChem. 2018 May 23;13(10):988-1003. doi: 10.1002/cmdc.201700783. Epub 2018 Apr 14.
ChemMedChem. 2018.
PMID: 29485740
Free PMC article.
Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases.
Bärfacker L, Kuhl A, Hillisch A, Grosser R, Figueroa-Pérez S, Heckroth H, Nitsche A, Ergüden JK, Gielen-Haertwig H, Schlemmer KH, Mittendorf J, Paulsen H, Platzek J, Kolkhof P.
Bärfacker L, et al. Among authors: erguden jk.
ChemMedChem. 2012 Aug;7(8):1385-403. doi: 10.1002/cmdc.201200081. Epub 2012 Jul 12.
ChemMedChem. 2012.
PMID: 22791416
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Selective indole-based ECE inhibitors: synthesis and pharmacological evaluation.
Brands M, Ergüden JK, Hashimoto K, Heimbach D, Krahn T, Schröder C, Siegel S, Stasch JP, Tsujishita H, Weigand S, Yoshida NH.
Brands M, et al. Among authors: erguden jk.
ChemMedChem. 2006 Jan;1(1):96-105. doi: 10.1002/cmdc.200500009.
ChemMedChem. 2006.
PMID: 16892341
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Novel, selective indole-based ECE inhibitors: lead optimization via solid-phase and classical synthesis.
Brands M, Ergüden JK, Hashimoto K, Heimbach D, Schröder C, Siegel S, Stasch JP, Weigand S.
Brands M, et al. Among authors: erguden jk.
Bioorg Med Chem Lett. 2005 Oct 1;15(19):4201-5. doi: 10.1016/j.bmcl.2005.06.085.
Bioorg Med Chem Lett. 2005.
PMID: 16085415
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Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor.
Wunder F, Tinel H, Kast R, Geerts A, Becker EM, Kolkhof P, Hütter J, Ergüden J, Härter M.
Wunder F, et al.
Br J Pharmacol. 2010 May;160(2):399-409. doi: 10.1111/j.1476-5381.2010.00730.x.
Br J Pharmacol. 2010.
PMID: 20423349
Free PMC article.
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A new tandem route to angular tetraquinanes. Synthesis of the Waihoensene ring system.
Ergüden JK, Moore HW.
Ergüden JK, et al.
Org Lett. 1999 Aug 12;1(3):375-7. doi: 10.1021/ol990023m.
Org Lett. 1999.
PMID: 10822579
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