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Nucleic acid-binding polymers as anti-inflammatory agents.
Lee J, Sohn JW, Zhang Y, Leong KW, Pisetsky D, Sullenger BA. Lee J, et al. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14055-60. doi: 10.1073/pnas.1105777108. Epub 2011 Aug 15. Proc Natl Acad Sci U S A. 2011. PMID: 21844380 Free PMC article.
Nucleic acid scavengers inhibit thrombosis without increasing bleeding.
Jain S, Pitoc GA, Holl EK, Zhang Y, Borst L, Leong KW, Lee J, Sullenger BA. Jain S, et al. Among authors: lee j. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12938-43. doi: 10.1073/pnas.1204928109. Epub 2012 Jul 25. Proc Natl Acad Sci U S A. 2012. PMID: 22837404 Free PMC article.
DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists.
Naqvi I, Giroux N, Olson L, Morrison SA, Llanga T, Akinade TO, Zhu Y, Zhong Y, Bose S, Arvai S, Abramson K, Chen L, Que L, Kraft B, Shen X, Lee J, Leong KW, Nair SK, Sullenger B. Naqvi I, et al. Among authors: lee j. Biomaterials. 2022 Apr;283:121393. doi: 10.1016/j.biomaterials.2022.121393. Epub 2022 Jan 28. Biomaterials. 2022. PMID: 35349874 Free PMC article.
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