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RNA-Targeted Therapeutics.
Crooke ST, Witztum JL, Bennett CF, Baker BF. Crooke ST, et al. Among authors: baker bf. Cell Metab. 2018 Apr 3;27(4):714-739. doi: 10.1016/j.cmet.2018.03.004. Cell Metab. 2018. PMID: 29617640 Free article. Review.
2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.
Baker BF, Lot SS, Condon TP, Cheng-Flournoy S, Lesnik EA, Sasmor HM, Bennett CF. Baker BF, et al. J Biol Chem. 1997 May 2;272(18):11994-2000. doi: 10.1074/jbc.272.18.11994. J Biol Chem. 1997. PMID: 9115264 Free article.
Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans.
Graham MJ, Lee RG, Bell TA 3rd, Fu W, Mullick AE, Alexander VJ, Singleton W, Viney N, Geary R, Su J, Baker BF, Burkey J, Crooke ST, Crooke RM. Graham MJ, et al. Among authors: baker bf. Circ Res. 2013 May 24;112(11):1479-90. doi: 10.1161/CIRCRESAHA.111.300367. Epub 2013 Mar 29. Circ Res. 2013. PMID: 23542898 Clinical Trial.
Targeting APOC3 in the familial chylomicronemia syndrome.
Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum JL. Gaudet D, et al. Among authors: baker bf. N Engl J Med. 2014 Dec 4;371(23):2200-6. doi: 10.1056/NEJMoa1400284. N Engl J Med. 2014. PMID: 25470695 Free article.
73 results