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Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling.
Lee JV, Berry CT, Kim K, Sen P, Kim T, Carrer A, Trefely S, Zhao S, Fernandez S, Barney LE, Schwartz AD, Peyton SR, Snyder NW, Berger SL, Freedman BD, Wellen KE. Lee JV, et al. Among authors: wellen ke. Genes Dev. 2018 Apr 1;32(7-8):497-511. doi: 10.1101/gad.311027.117. Epub 2018 Apr 19. Genes Dev. 2018. PMID: 29674394 Free PMC article.
Therapeutic targeting of ACLY in T-ALL in vivo.
da Silva-Diz V, Singh A, Lancho O, Aleksandrova M, Mandleywala K, Nunes PR, Khatun J, Kim O, Chiles E, Su X, Khiabanian H, Wellen KE, Herranz D. da Silva-Diz V, et al. Among authors: wellen ke. bioRxiv [Preprint]. 2023 Mar 28:2023.03.27.534395. doi: 10.1101/2023.03.27.534395. bioRxiv. 2023. PMID: 37034581 Free PMC article. Preprint.
IDH mutation impairs histone demethylation and results in a block to cell differentiation.
Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. Lu C, et al. Among authors: wellen ke. Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860. Nature. 2012. PMID: 22343901 Free PMC article.
Obesity, cancer, and acetyl-CoA metabolism.
Lee JV, Shah SA, Wellen KE. Lee JV, et al. Among authors: wellen ke. Drug Discov Today Dis Mech. 2013 Jun;10(1-2):e55-e61. doi: 10.1016/j.ddmec.2013.03.005. Drug Discov Today Dis Mech. 2013. PMID: 23878588 Free PMC article.
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE. Lee JV, et al. Among authors: wellen ke. Cell Metab. 2014 Aug 5;20(2):306-319. doi: 10.1016/j.cmet.2014.06.004. Epub 2014 Jul 3. Cell Metab. 2014. PMID: 24998913 Free PMC article.
Metabolism and epigenetics: a link cancer cells exploit.
Carrer A, Wellen KE. Carrer A, et al. Among authors: wellen ke. Curr Opin Biotechnol. 2015 Aug;34:23-9. doi: 10.1016/j.copbio.2014.11.012. Epub 2014 Nov 29. Curr Opin Biotechnol. 2015. PMID: 25461508 Free PMC article. Review.
86 results