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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
Pike KG, Barlaam B, Cadogan E, Campbell A, Chen Y, Colclough N, Davies NL, de-Almeida C, Degorce SL, Didelot M, Dishington A, Ducray R, Durant ST, Hassall LA, Holmes J, Hughes GD, MacFaul PA, Mulholland KR, McGuire TM, Ouvry G, Pass M, Robb G, Stratton N, Wang Z, Wilson J, Zhai B, Zhao K, Al-Huniti N. Pike KG, et al. Among authors: zhao k. J Med Chem. 2018 May 10;61(9):3823-3841. doi: 10.1021/acs.jmedchem.7b01896. Epub 2018 May 2. J Med Chem. 2018. PMID: 29683659
Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis.
Zhu X, Chen X, Cao Y, Liu C, Hu G, Ganesan S, Veres TZ, Fang D, Liu S, Chung H, Germain RN, Schwartzberg PL, Zhao K, Zhu J. Zhu X, et al. Among authors: zhao k. bioRxiv [Preprint]. 2024 May 20:2024.05.16.594397. doi: 10.1101/2024.05.16.594397. bioRxiv. 2024. PMID: 38903096 Free PMC article. Preprint.
Safety, Efficacy, and Pharmacokinetics of SHR-A1811, a Human Epidermal Growth Factor Receptor 2-Directed Antibody-Drug Conjugate, in Human Epidermal Growth Factor Receptor 2-Expressing or Mutated Advanced Solid Tumors: A Global Phase I Trial.
Yao H, Yan M, Tong Z, Wu X, Ryu MH, Park JJ, Kim JH, Zhong Y, Zhao Y, Voskoboynik M, Yin Y, Liu K, Kaubisch A, Liu C, Zhang J, Wang S, Im SA, Ganju V, Barve M, Li H, Ye C, Roy AC, Bai LY, Yen CJ, Gu S, Lin YC, Wu L, Bao L, Zhao K, Shen Y, Rong S, Zhu X, Song E. Yao H, et al. Among authors: zhao k. J Clin Oncol. 2024 Jun 20:JCO2302044. doi: 10.1200/JCO.23.02044. Online ahead of print. J Clin Oncol. 2024. PMID: 38900984
Knockdown of ATRX enhances radiosensitivity in glioblastoma.
Zhao Y, Chen Y, Liu R, Liu M, You N, Zhao K, Zhang J, Xu B. Zhao Y, et al. Among authors: zhao k. Chin Neurosurg J. 2024 Jun 19;10(1):19. doi: 10.1186/s41016-024-00371-6. Chin Neurosurg J. 2024. PMID: 38898533 Free PMC article.
7,384 results