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I-motif DNA structures are formed in the nuclei of human cells.
Zeraati M, Langley DB, Schofield P, Moye AL, Rouet R, Hughes WE, Bryan TM, Dinger ME, Christ D. Zeraati M, et al. Among authors: schofield p. Nat Chem. 2018 Jun;10(6):631-637. doi: 10.1038/s41557-018-0046-3. Epub 2018 Apr 23. Nat Chem. 2018. PMID: 29686376
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.
O'Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P, McLeod D, Cooper CL, McNeil CM, McFarland A, Nguyen A, Ormandy CJ, Qiu MR, Rabinovich B, Martelotto LG, Vu D, Hannigan GE, Musgrove EA, Christ D, Sutherland RL, Watkins DN, Swarbrick A. O'Toole SA, et al. Among authors: schofield p. Cancer Res. 2011 Jun 1;71(11):4002-14. doi: 10.1158/0008-5472.CAN-10-3738. Cancer Res. 2011. PMID: 21632555
Aggregation, stability, and formulation of human antibody therapeutics.
Lowe D, Dudgeon K, Rouet R, Schofield P, Jermutus L, Christ D. Lowe D, et al. Among authors: schofield p. Adv Protein Chem Struct Biol. 2011;84:41-61. doi: 10.1016/B978-0-12-386483-3.00004-5. Adv Protein Chem Struct Biol. 2011. PMID: 21846562 Review.
Expression of high-affinity human antibody fragments in bacteria.
Rouet R, Lowe D, Dudgeon K, Roome B, Schofield P, Langley D, Andrews J, Whitfeld P, Jermutus L, Christ D. Rouet R, et al. Among authors: schofield p. Nat Protoc. 2012 Feb 2;7(2):364-73. doi: 10.1038/nprot.2011.448. Nat Protoc. 2012. PMID: 22301775
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC. Sabouri Z, et al. Among authors: schofield p. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821781 Free PMC article. Clinical Trial.
FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.
Butt D, Chan TD, Bourne K, Hermes JR, Nguyen A, Statham A, O'Reilly LA, Strasser A, Price S, Schofield P, Christ D, Basten A, Ma CS, Tangye SG, Phan TG, Rao VK, Brink R. Butt D, et al. Among authors: schofield p. Immunity. 2015 May 19;42(5):890-902. doi: 10.1016/j.immuni.2015.04.010. Epub 2015 May 12. Immunity. 2015. PMID: 25979420 Free article.
Circumventing the stability-function trade-off in an engineered FN3 domain.
Porebski BT, Conroy PJ, Drinkwater N, Schofield P, Vazquez-Lombardi R, Hunter MR, Hoke DE, Christ D, McGowan S, Buckle AM. Porebski BT, et al. Among authors: schofield p. Protein Eng Des Sel. 2016 Nov 1;29(11):541-550. doi: 10.1093/protein/gzw046. Protein Eng Des Sel. 2016. PMID: 27578887 Free PMC article.
1,796 results