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Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.
Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N. Huang LC, et al. Among authors: kannan n. Sci Rep. 2018 Apr 25;8(1):6518. doi: 10.1038/s41598-018-24457-1. Sci Rep. 2018. PMID: 29695735 Free PMC article.
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.
Gould CM, Kannan N, Taylor SS, Newton AC. Gould CM, et al. Among authors: kannan n. J Biol Chem. 2009 Feb 20;284(8):4921-35. doi: 10.1074/jbc.M808436200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091746 Free PMC article.
The life cycle of protein kinase C (PKC) is tightly controlled by mechanisms that mature the enzyme, sustain the activation-competent enzyme, and degrade the enzyme. Here we show that a conserved PXXP motif (Kannan, N., Haste, N., Taylor, S. S., and Neuwald, …
The life cycle of protein kinase C (PKC) is tightly controlled by mechanisms that mature the enzyme, sustain the activation-competent enzyme …
ProKinO: a unified resource for mining the cancer kinome.
McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor SS, Kochut K, Kannan N. McSkimming DI, et al. Among authors: kannan n. Hum Mutat. 2015 Feb;36(2):175-86. doi: 10.1002/humu.22726. Hum Mutat. 2015. PMID: 25382819 Free PMC article.
Going for broke: targeting the human cancer pseudokinome.
Bailey FP, Byrne DP, McSkimming D, Kannan N, Eyers PA. Bailey FP, et al. Among authors: kannan n. Biochem J. 2015 Jan 15;465(2):195-211. doi: 10.1042/BJ20141060. Biochem J. 2015. PMID: 25559089 Review.
453 results