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LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Peltzer N, Darding M, Montinaro A, Draber P, Draberova H, Kupka S, Rieser E, Fisher A, Hutchinson C, Taraborrelli L, Hartwig T, Lafont E, Haas TL, Shimizu Y, Böiers C, Sarr A, Rickard J, Alvarez-Diaz S, Ashworth MT, Beal A, Enver T, Bertin J, Kaiser W, Strasser A, Silke J, Bouillet P, Walczak H. Peltzer N, et al. Among authors: kaiser w. Nature. 2018 May;557(7703):112-117. doi: 10.1038/s41586-018-0064-8. Epub 2018 Apr 25. Nature. 2018. PMID: 29695863 Free PMC article.
Is SIRT2 required for necroptosis?
Newton K, Hildebrand JM, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger DL, Huang C, Auwerx J, Vandenabeele P, Green DR, Ashkenazi A, Dixit VM, Kaiser WJ, Strasser A, Degterev A, Silke J. Newton K, et al. Nature. 2014 Feb 27;506(7489):E4-6. doi: 10.1038/nature13024. Nature. 2014. PMID: 24572428 Free PMC article.
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.
Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J. Rickard JA, et al. Elife. 2014 Dec 2;3:e03464. doi: 10.7554/eLife.03464. Elife. 2014. PMID: 25443632 Free PMC article.
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M. Jiao H, et al. Nature. 2020 Apr;580(7803):391-395. doi: 10.1038/s41586-020-2129-8. Epub 2020 Mar 25. Nature. 2020. PMID: 32296175 Free PMC article.
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ. Berger SB, et al. J Immunol. 2014 Jun 15;192(12):5476-80. doi: 10.4049/jimmunol.1400499. Epub 2014 May 12. J Immunol. 2014. PMID: 24821972 Free PMC article.
Herpes simplex virus suppresses necroptosis in human cells.
Guo H, Omoto S, Harris PA, Finger JN, Bertin J, Gough PJ, Kaiser WJ, Mocarski ES. Guo H, et al. Cell Host Microbe. 2015 Feb 11;17(2):243-51. doi: 10.1016/j.chom.2015.01.003. Cell Host Microbe. 2015. PMID: 25674983 Free PMC article.
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. Dovey CM, et al. Among authors: kaiser wj. Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7. Mol Cell. 2018. PMID: 29883610 Free PMC article.
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.
Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S. Nogusa S, et al. Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16. Cell Host Microbe. 2016. PMID: 27321907 Free PMC article.
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Weng D, et al. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6. doi: 10.1073/pnas.1403477111. Epub 2014 May 5. Proc Natl Acad Sci U S A. 2014. PMID: 24799678 Free PMC article.
1,184 results