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Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.
Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P. Brown RJ, et al. Among authors: startzell m. J Clin Invest. 2018 Aug 1;128(8):3504-3516. doi: 10.1172/JCI95476. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 29723161 Free PMC article. Clinical Trial.
Thyroid Abnormalities in Patients With Extreme Insulin Resistance Syndromes.
Kushchayeva YS, Kushchayev SV, Startzell M, Cochran E, Auh S, Dai Y, Lightbourne M, Skarulis M, Brown RJ. Kushchayeva YS, et al. Among authors: startzell m. J Clin Endocrinol Metab. 2019 Jun 1;104(6):2216-2228. doi: 10.1210/jc.2018-02289. J Clin Endocrinol Metab. 2019. PMID: 30657911 Free PMC article.
Leptin decreases de novo lipogenesis in patients with lipodystrophy.
Baykal AP, Parks EJ, Shamburek R, Syed-Abdul MM, Chacko S, Cochran E, Startzell M, Gharib AM, Ouwerkerk R, Abd-Elmoniem KZ, Walter PJ, Walter M, Muniyappa R, Chung ST, Brown RJ. Baykal AP, et al. Among authors: startzell m. JCI Insight. 2020 Jul 23;5(14):e137180. doi: 10.1172/jci.insight.137180. JCI Insight. 2020. PMID: 32573497 Free PMC article.
Visceral fat does not contribute to metabolic disease in lipodystrophy.
Malandrino N, Reynolds JC, Brychta RJ, Chen KY, Auh S, Gharib AM, Startzell M, Cochran EK, Brown RJ. Malandrino N, et al. Among authors: startzell m. Obes Sci Pract. 2019 Jan 24;5(1):75-82. doi: 10.1002/osp4.319. eCollection 2019 Feb. Obes Sci Pract. 2019. PMID: 30847226 Free PMC article.
Thyroid Hormone Effects on Glucose Disposal in Patients With Insulin Receptor Mutations.
Kushchayeva YS, Startzell M, Cochran E, Auh S, Sekizkardes H, Soldin SJ, Kushchayev SV, Dieckmann W, Skarulis M, Abdul Sater Z, Brychta RJ, Cypess AM, Lin TC, Lightbourne M, Millo C, Brown RJ. Kushchayeva YS, et al. Among authors: startzell m. J Clin Endocrinol Metab. 2020 Mar 1;105(3):e158-71. doi: 10.1210/clinem/dgz079. J Clin Endocrinol Metab. 2020. PMID: 31588494 Free PMC article. Clinical Trial.
Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy.
Lightbourne M, Startzell M, Bruce KD, Brite B, Muniyappa R, Skarulis M, Shamburek R, Gharib AM, Ouwerkerk R, Walter M, Eckel RH, Brown RJ. Lightbourne M, et al. Among authors: startzell m. J Clin Lipidol. 2022 Nov-Dec;16(6):850-862. doi: 10.1016/j.jacl.2022.06.011. Epub 2022 Sep 22. J Clin Lipidol. 2022. PMID: 36195542 Free PMC article. Clinical Trial.
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