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Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide.
Nat Chem. 2018 Jul;10(7):787-794. doi: 10.1038/s41557-018-0055-2. Epub 2018 May 14.
Nat Chem. 2018.
PMID: 29760413
Free PMC article.
pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates.
Ji X, De La Cruz LKC, Pan Z, Chittavong V, Wang B.
Ji X, et al. Among authors: de la cruz lkc.
Chem Commun (Camb). 2017 Aug 24;53(69):9628-9631. doi: 10.1039/c7cc04866a.
Chem Commun (Camb). 2017.
PMID: 28809970
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Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter.
De La Cruz LKC, Benoit SL, Pan Z, Yu B, Maier RJ, Ji X, Wang B.
De La Cruz LKC, et al.
Org Lett. 2018 Feb 16;20(4):897-900. doi: 10.1021/acs.orglett.7b03348. Epub 2018 Jan 30.
Org Lett. 2018.
PMID: 29380605
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Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation.
Ji X, Pan Z, Li C, Kang T, De La Cruz LKC, Yang L, Yuan Z, Ke B, Wang B.
Ji X, et al. Among authors: de la cruz lkc.
J Med Chem. 2019 Mar 28;62(6):3163-3168. doi: 10.1021/acs.jmedchem.9b00073. Epub 2019 Mar 14.
J Med Chem. 2019.
PMID: 30816714
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Click and Release: A High-Content Bioorthogonal Prodrug with Multiple Outputs.
Ji X, Aghoghovbia RE, De La Cruz LKC, Pan Z, Yang X, Yu B, Wang B.
Ji X, et al. Among authors: de la cruz lkc.
Org Lett. 2019 May 17;21(10):3649-3652. doi: 10.1021/acs.orglett.9b01086. Epub 2019 May 7.
Org Lett. 2019.
PMID: 31063383
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Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.
Draganov AB, Yang X, Anifowose A, De La Cruz LKC, Dai C, Ni N, Chen W, De Los Santos Z, Gu L, Zhou M, Wang B.
Draganov AB, et al. Among authors: de la cruz lkc.
Bioorg Med Chem. 2019 Sep 1;27(17):3860-3865. doi: 10.1016/j.bmc.2019.07.019. Epub 2019 Jul 11.
Bioorg Med Chem. 2019.
PMID: 31324563
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