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Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.
Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, De Carvalho DD, McGaha TL. Shinde R, et al. Among authors: manion kp. Nat Immunol. 2018 Jun;19(6):571-582. doi: 10.1038/s41590-018-0107-1. Epub 2018 May 14. Nat Immunol. 2018. PMID: 29760532 Free PMC article.
The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease.
Baglaenko Y, Chang NH, Johnson SR, Hafiz W, Manion K, Ferri D, Noamani B, Bonilla D, Rusta-Sellehy S, Lisnevskaia L, Silverman E, Bookman A, Landolt-Marticorena C, Wither J. Baglaenko Y, et al. Arthritis Res Ther. 2018 Nov 29;20(1):264. doi: 10.1186/s13075-018-1752-3. Arthritis Res Ther. 2018. PMID: 30486869 Free PMC article.
Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies.
Gupta R, Vanlieshout E, Manion K, Bonilla D, Kim M, Muñoz-Grajales C, Nassar C, Johnson SR, Hiraki LT, Ahmad Z, Touma Z, Bookman A, Wither JE. Gupta R, et al. Front Immunol. 2022 Jun 30;13:886442. doi: 10.3389/fimmu.2022.886442. eCollection 2022. Front Immunol. 2022. PMID: 35844549 Free PMC article.
11 results