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Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.
Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S. Saha LK, et al. Among authors: choi k. Environ Mol Mutagen. 2018 Jul;59(6):529-538. doi: 10.1002/em.22201. Epub 2018 May 15. Environ Mol Mutagen. 2018. PMID: 29761828
Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.
Smith S, Fox J, Mejia M, Ruangpradit W, Saberi A, Kim S, Choi Y, Oh S, Wang Y, Choi K, Li L, Hendrickson EA, Takeda S, Muller M, Myung K. Smith S, et al. Among authors: choi y, choi k. PLoS One. 2014 Jan 23;9(1):e87203. doi: 10.1371/journal.pone.0087203. eCollection 2014. PLoS One. 2014. PMID: 24466340 Free PMC article.
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