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Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. Saiki JP, et al. Among authors: knox sm. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6279-6284. doi: 10.1073/pnas.1802184115. Epub 2018 May 24. Proc Natl Acad Sci U S A. 2018. PMID: 29794221 Free PMC article.
Salivary gland development and disease.
Mattingly A, Finley JK, Knox SM. Mattingly A, et al. Among authors: knox sm. Wiley Interdiscip Rev Dev Biol. 2015 Nov-Dec;4(6):573-90. doi: 10.1002/wdev.194. Epub 2015 May 13. Wiley Interdiscip Rev Dev Biol. 2015. PMID: 25970268 Free PMC article. Review.
Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.
Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. Viswanathan V, et al. PNAS Nexus. 2022 Jun 9;1(2):pgac056. doi: 10.1093/pnasnexus/pgac056. eCollection 2022 May. PNAS Nexus. 2022. PMID: 35707206 Free PMC article.
SOX2 regulates acinar cell development in the salivary gland.
Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. Emmerson E, et al. Among authors: knox sm. Elife. 2017 Jun 17;6:e26620. doi: 10.7554/eLife.26620. Elife. 2017. PMID: 28623666 Free PMC article.
57 results