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Page 1
Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway.
Miranda MM, Panis C, da Silva SS, Macri JA, Kawakami NY, Hayashida TH, Madeira TB, Acquaro VR Jr, Nixdorf SL, Pizzatti L, Ambrósio SR, Cecchini R, Arakawa NS, Verri WA Jr, Costa IC, Pavanelli WR. Miranda MM, et al. Among authors: arakawa ns. Mediators Inflamm. 2015;2015:392918. doi: 10.1155/2015/392918. Epub 2015 May 13. Mediators Inflamm. 2015. PMID: 26074677 Free PMC article.
Pimaradienoic Acid Inhibits Carrageenan-Induced Inflammatory Leukocyte Recruitment and Edema in Mice: Inhibition of Oxidative Stress, Nitric Oxide and Cytokine Production.
Mizokami SS, Hohmann MS, Staurengo-Ferrari L, Carvalho TT, Zarpelon AC, Possebon MI, de Souza AR, Veneziani RC, Arakawa NS, Casagrande R, Verri WA Jr. Mizokami SS, et al. Among authors: arakawa ns. PLoS One. 2016 Feb 19;11(2):e0149656. doi: 10.1371/journal.pone.0149656. eCollection 2016. PLoS One. 2016. PMID: 26895409 Free PMC article.
Kaurenoic acid extracted from Sphagneticola trilobata reduces acetaminophen-induced hepatotoxicity through inhibition of oxidative stress and pro-inflammatory cytokine production in mice.
Marcondes-Alves L, Fattori V, Borghi SM, Lourenco-Gonzalez Y, Bussmann AJC, Hirooka EY, Casagrande R, Verri WA Jr, Arakawa NS. Marcondes-Alves L, et al. Among authors: arakawa ns. Nat Prod Res. 2019 Mar;33(6):921-924. doi: 10.1080/14786419.2017.1416372. Epub 2017 Dec 20. Nat Prod Res. 2019. PMID: 29262719
Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis.
Gonçalves MD, Bortoleti BTS, Tomiotto-Pellissier F, Miranda-Sapla MM, Assolini JP, Carloto ACM, Carvalho PGC, Tudisco ET, Urbano A, Ambrósio SR, Hirooka EY, Simão ANC, Costa IN, Pavanelli WR, Conchon-Costa I, Arakawa NS. Gonçalves MD, et al. Among authors: arakawa ns. Fitoterapia. 2018 Jul;128:224-232. doi: 10.1016/j.fitote.2018.05.027. Epub 2018 May 23. Fitoterapia. 2018. PMID: 29802873
Grandiflorenic acid promotes death of promastigotes via apoptosis-like mechanism and affects amastigotes by increasing total iron bound capacity.
Bortoleti BTDS, Gonçalves MD, Tomiotto-Pellissier F, Miranda-Sapla MM, Assolini JP, Carloto ACM, de Carvalho PGC, Cardoso ILA, Simão ANC, Arakawa NS, Costa IN, Conchon-Costa I, Pavanelli WR. Bortoleti BTDS, et al. Among authors: arakawa ns. Phytomedicine. 2018 Jul 15;46:11-20. doi: 10.1016/j.phymed.2018.06.010. Epub 2018 Jun 13. Phytomedicine. 2018. PMID: 30097110
Solidagenone acts on promastigotes of L. amazonensis by inducing apoptosis-like processes on intracellular amastigotes by IL-12p70/ROS/NO pathway activation.
Bortoleti BTDS, Gonçalves MD, Tomiotto-Pellissier F, Contato VM, Silva TF, de Matos RLN, Detoni MB, Rodrigues ACJ, Carloto AC, Lazarin DB, Arakawa NS, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Wowk PF, Pavanelli WR. Bortoleti BTDS, et al. Among authors: arakawa ns. Phytomedicine. 2021 May;85:153536. doi: 10.1016/j.phymed.2021.153536. Epub 2021 Mar 3. Phytomedicine. 2021. PMID: 33765552
Sphagneticola trilobata (L.) Pruski-derived kaurenoic acid prevents ovalbumin-induced asthma in mice: Effect on Th2 cytokines, STAT6/GATA-3 signaling, NFκB/Nrf2 redox sensitive pathways, and regulatory T cell phenotype markers.
Borghi SM, Domiciano TP, Rasquel-Oliveira FS, Ferraz CR, Bussmann AJC, Vignoli JA, Camilios-Neto D, Ambrósio SR, Arakawa NS, Casagrande R, Verri WA Jr. Borghi SM, et al. Among authors: arakawa ns. J Ethnopharmacol. 2022 Jan 30;283:114708. doi: 10.1016/j.jep.2021.114708. Epub 2021 Oct 4. J Ethnopharmacol. 2022. PMID: 34619320 Free article.
Grandiflorenic acid isolated from Sphagneticola trilobata against Trypanosoma cruzi: Toxicity, mechanisms of action and immunomodulation.
Gonçalves MD, Bortoleti BTDS, Tomiotto-Pellissier F, Concato VM, de Matos RLN, Silva TF, Rodrigues ACJ, Carloto ACM, Costa IN, Lazarin-Bidóia D, Miranda-Sapla MM, Pavanelli WR, Arakawa NS, Conchon-Costa I. Gonçalves MD, et al. Among authors: arakawa ns. Toxicol In Vitro. 2022 Feb;78:105267. doi: 10.1016/j.tiv.2021.105267. Epub 2021 Oct 22. Toxicol In Vitro. 2022. PMID: 34688839
Recent Advances in Biotransformation by Cunninghamella Species.
Gonçalves MD, Tomiotto-Pellissier F, de Matos RLN, Assolini JP, da Silva Bortoleti BT, Concato VM, Silva TF, Rafael JA, Pavanelli WR, Conchon-Costa I, Arakawa NS. Gonçalves MD, et al. Among authors: arakawa ns. Curr Drug Metab. 2021;22(13):1035-1064. doi: 10.2174/1389200222666211126100023. Curr Drug Metab. 2021. PMID: 34825868 Review.
40 results