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Page 1
The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells.
Gonçalves Silva I, Yasinska IM, Sakhnevych SS, Fiedler W, Wellbrock J, Bardelli M, Varani L, Hussain R, Siligardi G, Ceccone G, Berger SM, Ushkaryov YA, Gibbs BF, Fasler-Kan E, Sumbayev VV. Gonçalves Silva I, et al. Among authors: sakhnevych ss. EBioMedicine. 2017 Aug;22:44-57. doi: 10.1016/j.ebiom.2017.07.018. Epub 2017 Jul 19. EBioMedicine. 2017. PMID: 28750861 Free PMC article.
Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.
Sakhnevych SS, Yasinska IM, Bratt AM, Benlaouer O, Gonçalves Silva I, Hussain R, Siligardi G, Fiedler W, Wellbrock J, Gibbs BF, Ushkaryov YA, Sumbayev VV. Sakhnevych SS, et al. Cell Mol Immunol. 2018 Nov;15(11):994-997. doi: 10.1038/s41423-018-0053-8. Epub 2018 Jun 15. Cell Mol Immunol. 2018. PMID: 29907881 Free PMC article. No abstract available.
The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer.
Yasinska IM, Sakhnevych SS, Pavlova L, Teo Hansen Selnø A, Teuscher Abeleira AM, Benlaouer O, Gonçalves Silva I, Mosimann M, Varani L, Bardelli M, Hussain R, Siligardi G, Cholewa D, Berger SM, Gibbs BF, Ushkaryov YA, Fasler-Kan E, Klenova E, Sumbayev VV. Yasinska IM, et al. Among authors: sakhnevych ss. Front Immunol. 2019 Jul 11;10:1594. doi: 10.3389/fimmu.2019.01594. eCollection 2019. Front Immunol. 2019. PMID: 31354733 Free PMC article.
Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells.
Selnø ATH, Schlichtner S, Yasinska IM, Sakhnevych SS, Fiedler W, Wellbrock J, Klenova E, Pavlova L, Gibbs BF, Degen M, Schnyder I, Aliu N, Berger SM, Fasler-Kan E, Sumbayev VV. Selnø ATH, et al. Among authors: sakhnevych ss. Aging (Albany NY). 2020 Dec 8;12(23):23478-23496. doi: 10.18632/aging.202343. Epub 2020 Dec 8. Aging (Albany NY). 2020. PMID: 33295886 Free PMC article.
High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells.
Teo Hansen Selnø A, Schlichtner S, Yasinska IM, Sakhnevych SS, Fiedler W, Wellbrock J, Berger SM, Klenova E, Gibbs BF, Fasler-Kan E, Sumbayev VV. Teo Hansen Selnø A, et al. Among authors: sakhnevych ss. Front Immunol. 2021 Jun 21;12:675731. doi: 10.3389/fimmu.2021.675731. eCollection 2021. Front Immunol. 2021. PMID: 34234778 Free PMC article.
High mobility group box 1 (HMGB1) acts as an "alarmin" to promote acute myeloid leukaemia progression.
Yasinska IM, Gonçalves Silva I, Sakhnevych SS, Ruegg L, Hussain R, Siligardi G, Fiedler W, Wellbrock J, Bardelli M, Varani L, Raap U, Berger S, Gibbs BF, Fasler-Kan E, Sumbayev VV. Yasinska IM, et al. Among authors: sakhnevych ss. Oncoimmunology. 2018 Feb 27;7(6):e1438109. doi: 10.1080/2162402X.2018.1438109. eCollection 2018. Oncoimmunology. 2018. PMID: 29872582 Free PMC article.
Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data.
Fisher NC, Byrne RM, Leslie H, Wood C, Legrini A, Cameron AJ, Ahmaderaghi B, Corry SM, Malla SB, Amirkhah R, McCooey AJ, Rogan E, Redmond KL, Sakhnevych S, Domingo E, Jackson J, Loughrey MB, Leedham S, Maughan T, Lawler M, Sansom OJ, Lamrock F, Koelzer VH, Jamieson NB, Dunne PD. Fisher NC, et al. Among authors: sakhnevych s. Clin Cancer Res. 2022 Sep 15;28(18):4056-4069. doi: 10.1158/1078-0432.CCR-22-1102. Clin Cancer Res. 2022. PMID: 35792866 Free PMC article.
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Corry SM, McCorry AM, Lannagan TR, Leonard NA, Fisher NC, Byrne RM, Tsantoulis P, Cortes-Lavaud X, Amirkhah R, Redmond KL, McCooey AJ, Malla SB, Rogan E, Sakhnevych S, Gillespie MA, White M, Richman SD, Jackstadt RF, Campbell AD, Maguire S; S:CORT and ACRCelerate consortia; McDade SS, Longley DB, Loughrey MB, Coleman HG, Kerr EM, Tejpar S, Maughan T, Leedham SJ, Small DM, Ryan AE, Sansom OJ, Lawler M, Dunne PD. Corry SM, et al. Among authors: sakhnevych s. Gut. 2022 Dec;71(12):2502-2517. doi: 10.1136/gutjnl-2021-326183. Epub 2022 Apr 27. Gut. 2022. PMID: 35477539 Free PMC article.
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