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Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.
Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W. Yang S, et al. Among authors: huang ct, huang r, huang w. Cell Discov. 2018 Jun 5;4:31. doi: 10.1038/s41421-018-0034-1. eCollection 2018. Cell Discov. 2018. PMID: 29872540 Free PMC article.
Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.
Yuan P, Tragon T, Xia M, Leclair CA, Skoumbourdis AP, Zheng W, Thomas CJ, Huang R, Austin CP, Chen G, Guitart X. Yuan P, et al. Among authors: huang r. Pharmacol Biochem Behav. 2011 May;98(3):349-55. doi: 10.1016/j.pbb.2011.02.001. Epub 2011 Feb 4. Pharmacol Biochem Behav. 2011. PMID: 21296104 Free PMC article.
Paradigm shift in toxicity testing and modeling.
Sun H, Xia M, Austin CP, Huang R. Sun H, et al. Among authors: huang r. AAPS J. 2012 Sep;14(3):473-80. doi: 10.1208/s12248-012-9358-1. Epub 2012 Apr 20. AAPS J. 2012. PMID: 22528508 Free PMC article. Review.
Identification of repurposed small molecule drugs for chordoma therapy.
Xia M, Huang R, Sakamuru S, Alcorta D, Cho MH, Lee DH, Park DM, Kelley MJ, Sommer J, Austin CP. Xia M, et al. Among authors: huang r. Cancer Biol Ther. 2013 Jul;14(7):638-47. doi: 10.4161/cbt.24596. Epub 2013 May 10. Cancer Biol Ther. 2013. PMID: 23792643 Free PMC article.
Are hERG channel blockers also phospholipidosis inducers?
Sun H, Xia M, Shahane SA, Jadhav A, Austin CP, Huang R. Sun H, et al. Among authors: huang r. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4587-90. doi: 10.1016/j.bmcl.2013.06.034. Epub 2013 Jun 20. Bioorg Med Chem Lett. 2013. PMID: 23856051 Free PMC article.
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