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A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release.
Alcaino C, Knutson KR, Treichel AJ, Yildiz G, Strege PR, Linden DR, Li JH, Leiter AB, Szurszewski JH, Farrugia G, Beyder A. Alcaino C, et al. Among authors: szurszewski jh. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7632-E7641. doi: 10.1073/pnas.1804938115. Epub 2018 Jul 23. Proc Natl Acad Sci U S A. 2018. PMID: 30037999 Free PMC article.
Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.
Treichel AJ, Finholm I, Knutson KR, Alcaino C, Whiteman ST, Brown MR, Matveyenko A, Wegner A, Kacmaz H, Mercado-Perez A, Gajdos GB, Ordog T, Grover M, Szurszewski J, Linden DR, Farrugia G, Beyder A. Treichel AJ, et al. Gastroenterology. 2022 Feb;162(2):535-547.e13. doi: 10.1053/j.gastro.2021.10.026. Epub 2021 Oct 22. Gastroenterology. 2022. PMID: 34688712 Free PMC article.
Sodium current in human intestinal interstitial cells of Cajal.
Strege PR, Ou Y, Sha L, Rich A, Gibbons SJ, Szurszewski JH, Sarr MG, Farrugia G. Strege PR, et al. Among authors: szurszewski jh. Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1111-21. doi: 10.1152/ajpgi.00152.2003. Epub 2003 Jul 31. Am J Physiol Gastrointest Liver Physiol. 2003. PMID: 12893628 Free article.
Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5.
Strege PR, Bernard CE, Kraichely RE, Mazzone A, Sha L, Beyder A, Gibbons SJ, Linden DR, Kendrick ML, Sarr MG, Szurszewski JH, Farrugia G. Strege PR, et al. Among authors: szurszewski jh. Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G1105-14. doi: 10.1152/ajpgi.00556.2010. Epub 2011 Mar 10. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21393430 Free PMC article.
Sodium current in human jejunal circular smooth muscle cells.
Holm AN, Rich A, Miller SM, Strege P, Ou Y, Gibbons S, Sarr MG, Szurszewski JH, Rae JL, Farrugia G. Holm AN, et al. Among authors: szurszewski jh. Gastroenterology. 2002 Jan;122(1):178-87. doi: 10.1053/gast.2002.30346. Gastroenterology. 2002. PMID: 11781292
202 results