Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.
Boccella S, Guida F, De Logu F, De Gregorio D, Mazzitelli M, Belardo C, Iannotta M, Serra N, Nassini R, de Novellis V, Geppetti P, Maione S, Luongo L.
Boccella S, et al. Among authors: de gregorio d, de logu f, de novellis v.
FASEB J. 2019 Jan;33(1):1062-1073. doi: 10.1096/fj.201801033R. Epub 2018 Aug 7.
FASEB J. 2019.
PMID: 30085883
This effect was completely lost in the HCAR2-null mice after a 2-d starvation protocol, in which the BHB reached the concentration able to activate the HCAR2-reduced tactile allodynia in female WT mice, but not in the HCAR2-null mice. ...Our results pave the way for invest …
This effect was completely lost in the HCAR2-null mice after a 2-d starvation protocol, in which the BHB reached the concentration ab …