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The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW. Zehender A, et al. Among authors: zhang zy. Nat Commun. 2018 Aug 14;9(1):3259. doi: 10.1038/s41467-018-05768-3. Nat Commun. 2018. PMID: 30108215 Free PMC article.
SHP2 phosphatase as a novel therapeutic target for melanoma treatment.
Zhang RY, Yu ZH, Zeng L, Zhang S, Bai Y, Miao J, Chen L, Xie J, Zhang ZY. Zhang RY, et al. Among authors: zhang s, zhang zy. Oncotarget. 2016 Nov 8;7(45):73817-73829. doi: 10.18632/oncotarget.12074. Oncotarget. 2016. PMID: 27650545 Free PMC article.
PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. Sacchetti C, et al. Among authors: zhang zy. Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1. Nat Commun. 2017. PMID: 29057934 Free PMC article.
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Kano Y, Gebregiworgis T, Marshall CB, Radulovich N, Poon BPK, St-Germain J, Cook JD, Valencia-Sama I, Grant BMM, Herrera SG, Miao J, Raught B, Irwin MS, Lee JE, Yeh JJ, Zhang ZY, Tsao MS, Ikura M, Ohh M. Kano Y, et al. Among authors: zhang zy. Nat Commun. 2019 Jan 15;10(1):224. doi: 10.1038/s41467-018-08115-8. Nat Commun. 2019. PMID: 30644389 Free PMC article.
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Gebregiworgis T, Kano Y, St-Germain J, Radulovich N, Udaskin ML, Mentes A, Huang R, Poon BPK, He W, Valencia-Sama I, Robinson CM, Huestis M, Miao J, Yeh JJ, Zhang ZY, Irwin MS, Lee JE, Tsao MS, Raught B, Marshall CB, Ohh M, Ikura M. Gebregiworgis T, et al. Among authors: zhang zy. Nat Commun. 2021 Nov 1;12(1):6274. doi: 10.1038/s41467-021-26526-y. Nat Commun. 2021. PMID: 34725361 Free PMC article.
An Integrated Proteomic Strategy to Identify SHP2 Substrates.
Zhu P, Wu X, Zhang RY, Hsu CC, Zhang ZY, Tao WA. Zhu P, et al. Among authors: zhang ry, zhang zy. J Proteome Res. 2022 Oct 7;21(10):2515-2525. doi: 10.1021/acs.jproteome.2c00481. Epub 2022 Sep 14. J Proteome Res. 2022. PMID: 36103635 Free PMC article.
3,462 results