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Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
D'Souza AM, Jiang Y, Cast A, Valanejad L, Wright M, Lewis K, Kumbaji M, Shah S, Smithrud D, Karns R, Shin S, Timchenko N. D'Souza AM, et al. Among authors: lewis k. Cell Mol Gastroenterol Hepatol. 2018 May 24;6(3):239-255. doi: 10.1016/j.jcmgh.2018.05.007. eCollection 2018. Cell Mol Gastroenterol Hepatol. 2018. PMID: 30109252 Free PMC article.
FXR-Gankyrin axis is involved in development of pediatric liver cancer.
Valanejad L, Lewis K, Wright M, Jiang Y, D'Souza A, Karns R, Sheridan R, Gupta A, Bove K, Witte D, Geller J, Tiao G, Nelson DL, Timchenko L, Timchenko N. Valanejad L, et al. Among authors: lewis k. Carcinogenesis. 2017 Jul 1;38(7):738-747. doi: 10.1093/carcin/bgx050. Carcinogenesis. 2017. PMID: 28535186 Free PMC article.
Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.
Jin J, Iakova P, Jiang Y, Lewis K, Sullivan E, Jawanmardi N, Donehower L, Timchenko L, Timchenko NA. Jin J, et al. Among authors: lewis k. J Biol Chem. 2013 May 17;288(20):14451-14462. doi: 10.1074/jbc.M113.460840. Epub 2013 Apr 5. J Biol Chem. 2013. PMID: 23564453 Free PMC article.
Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.
Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T. Ouchi R, et al. Among authors: lewis k. Cell Metab. 2019 Aug 6;30(2):374-384.e6. doi: 10.1016/j.cmet.2019.05.007. Epub 2019 May 30. Cell Metab. 2019. PMID: 31155493 Free PMC article.
High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids.
Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson WL, Asai A, Takebe T. Shinozawa T, et al. Among authors: lewis k. Gastroenterology. 2021 Feb;160(3):831-846.e10. doi: 10.1053/j.gastro.2020.10.002. Epub 2020 Oct 8. Gastroenterology. 2021. PMID: 33039464 Free PMC article.
2,485 results