Clark L - Search Results

1

On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies.

Clark L, Dikiy I, Rosenbaum DM, Gardner KH. Clark L, et al. J Biomol NMR. 2018 Aug;71(4):203-211. doi: 10.1007/s10858-018-0204-3. Epub 2018 Aug 18. J Biomol NMR. 2018. PMID: 30121871 Free PMC article. Review.

2

Improved strategy for isoleucine ¹H/¹³C methyl labeling in Pichia pastoris.

Ali R, Clark LD, Zahm JA, Lemoff A, Ramesh K, Rosenbaum DM, Rosen MK. Ali R, et al. J Biomol NMR. 2019 Dec;73(12):687-697. doi: 10.1007/s10858-019-00281-1. Epub 2019 Sep 20. J Biomol NMR. 2019. PMID: 31541396 Free PMC article.

3

Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics.

Dikiy I, Clark LD, Gardner KH, Rosenbaum DM. Dikiy I, et al. Methods Enzymol. 2019;614:37-65. doi: 10.1016/bs.mie.2018.08.030. Epub 2018 Dec 18. Methods Enzymol. 2019. PMID: 30611431 Free PMC article.

4

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Clark L, et al. J Biomol NMR. 2015 Jul;62(3):239-45. doi: 10.1007/s10858-015-9939-2. Epub 2015 May 30. J Biomol NMR. 2015. PMID: 26025061 Free PMC article.

5

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Clark L, et al. J Biomol NMR. 2016 Mar;64(3):267. doi: 10.1007/s10858-016-0016-2. J Biomol NMR. 2016. PMID: 26894386 Free PMC article. No abstract available.

6

Ligand modulation of sidechain dynamics in a wild-type human GPCR.

Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM. Clark LD, et al. Elife. 2017 Oct 6;6:e28505. doi: 10.7554/eLife.28505. Elife. 2017. PMID: 28984574 Free PMC article.

7

High-resolution crystal structure of the human CB1 cannabinoid receptor.

Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM. Shao Z, et al. Among authors: clark l. Nature. 2016 Dec 22;540(7634):602-606. doi: 10.1038/nature20613. Epub 2016 Nov 16. Nature. 2016. PMID: 27851727 Free PMC article.

8

Crystal structure of the human NK₁ tachykinin receptor.

Yin J, Chapman K, Clark LD, Shao Z, Borek D, Xu Q, Wang J, Rosenbaum DM. Yin J, et al. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13264-13269. doi: 10.1073/pnas.1812717115. Epub 2018 Dec 11. Proc Natl Acad Sci U S A. 2018. PMID: 30538204 Free PMC article.

9

Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.

Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM. Kober DL, et al. Among authors: clark ld. Cell. 2021 Jul 8;184(14):3689-3701.e22. doi: 10.1016/j.cell.2021.05.019. Epub 2021 Jun 16. Cell. 2021. PMID: 34139175 Free PMC article.

10

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.

Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM. Yin J, et al. Among authors: clark l. Nat Struct Mol Biol. 2016 Apr;23(4):293-9. doi: 10.1038/nsmb.3183. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950369

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