Iio K - Search Results

1

Identification of inactive conformation-selective interleukin-2-inducible T-cell kinase (ITK) inhibitors based on second-harmonic generation.

Hantani Y, Iio K, Hantani R, Umetani K, Sato T, Young T, Connell K, Kintz S, Salafsky J. Hantani Y, et al. Among authors: iio k. FEBS Open Bio. 2018 Jul 30;8(9):1412-1423. doi: 10.1002/2211-5463.12489. eCollection 2018 Sep. FEBS Open Bio. 2018. PMID: 30186743 Free PMC article.

2

Discovery of pyrrolopyridazines as novel DGAT1 inhibitors.

Fox BM, Iio K, Li K, Choi R, Inaba T, Jackson S, Sagawa S, Shan B, Tanaka M, Yoshida A, Kayser F. Fox BM, et al. Among authors: iio k. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6030-3. doi: 10.1016/j.bmcl.2010.08.066. Epub 2010 Aug 18. Bioorg Med Chem Lett. 2010. PMID: 20833038

3

Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling.

Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F. Katsuya K, et al. Among authors: iio k. Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706. doi: 10.1016/j.bbrc.2018.12.164. Epub 2019 Jan 2. Biochem Biophys Res Commun. 2019. PMID: 30611571

4

Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.

Fox BM, Sugimoto K, Iio K, Yoshida A, Zhang JK, Li K, Hao X, Labelle M, Smith ML, Rubenstein SM, Ye G, McMinn D, Jackson S, Choi R, Shan B, Ma J, Miao S, Matsui T, Ogawa N, Suzuki M, Kobayashi A, Ozeki H, Okuma C, Ishii Y, Tomimoto D, Furakawa N, Tanaka M, Matsushita M, Takahashi M, Inaba T, Sagawa S, Kayser F. Fox BM, et al. Among authors: iio k. J Med Chem. 2014 Apr 24;57(8):3464-83. doi: 10.1021/jm500135c. Epub 2014 Apr 8. J Med Chem. 2014. PMID: 24670009

5

Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.

Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F. Oikawa D, et al. Among authors: iio k. Commun Biol. 2020 Apr 3;3(1):163. doi: 10.1038/s42003-020-0882-8. Commun Biol. 2020. PMID: 32246052 Free PMC article.

6

Asymmetric total synthesis of fredericamycin A: an intramolecular cycloaddition pathway.

Akai S, Tsujino T, Fukuda N, Iio K, Takeda Y, Kawaguchi K, Naka T, Higuchi K, Akiyama E, Fujioka H, Kita Y. Akai S, et al. Among authors: iio k. Chemistry. 2005 Oct 21;11(21):6286-97. doi: 10.1002/chem.200500443. Chemistry. 2005. PMID: 16075440

7

Asymmetric Total Synthesis of Fredericamycin A.

Kita Y, Higuchi K, Yoshida Y, Iio K, Kitagaki S, Akai S, Fujioka H. Kita Y, et al. Among authors: iio k. Angew Chem Int Ed Engl. 1999 Mar 1;38(5):683-686. doi: 10.1002/(SICI)1521-3773(19990301)38:5<683::AID-ANIE683>3.0.CO;2-0. Angew Chem Int Ed Engl. 1999. PMID: 29711553

8

Total synthesis of the antitumor antibiotic (+/-)-fredericamycin A by a linear approach.

Kita Y, Iio K, Kawaguchi K, Fukuda N, Takeda Y, Ueno H, Okunaka R, Higuchi K, Tsujino T, Fujioka H, Akai S. Kita Y, et al. Among authors: iio k. Chemistry. 2000 Nov 3;6(21):3897-905. doi: 10.1002/1521-3765(20001103)6:21<3897::aid-chem3897>3.0.co;2-1. Chemistry. 2000. PMID: 11126950

9

Enantioselective total synthesis of a potent antitumor antibiotic, fredericamycin A.

Kita Y, Higuchi K, Yoshida Y, Iio K, Kitagaki S, Ueda K, Akai S, Fujioka H. Kita Y, et al. Among authors: iio k. J Am Chem Soc. 2001 Apr 11;123(14):3214-22. doi: 10.1021/ja0035699. J Am Chem Soc. 2001. PMID: 11457055

10

Enantiodivergent synthesis of either enantiomer of ABCDE-ring analogue of antitumor antibiotic fredericamycin A via intramolecular [4 + 2] cycloaddition approach.

Akai S, Tsujino T, Fukuda N, Iio K, Takeda Y, Kawaguchi Ki K, Naka T, Higuchi K, Kita Y. Akai S, et al. Among authors: iio k. Org Lett. 2001 Dec 13;3(25):4015-8. doi: 10.1021/ol016696y. Org Lett. 2001. PMID: 11735573

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