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The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells.
Mutagenesis. 2018 Oct 11;33(4):311-321. doi: 10.1093/mutage/gey025.
Mutagenesis. 2018.
PMID: 30215795
Free PMC article.
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.
Wohak LE, Krais AM, Kucab JE, Stertmann J, Øvrebø S, Seidel A, Phillips DH, Arlt VM.
Wohak LE, et al.
Arch Toxicol. 2016 Feb;90(2):291-304. doi: 10.1007/s00204-014-1409-1. Epub 2014 Nov 15.
Arch Toxicol. 2016.
PMID: 25398514
Free PMC article.
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The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells.
Willis AJ, Indra R, Wohak LE, Sozeri O, Feser K, Mrizova I, Phillips DH, Stiborova M, Arlt VM.
Willis AJ, et al. Among authors: wohak le.
Toxicology. 2018 Apr 1;398-399:1-12. doi: 10.1016/j.tox.2018.02.006. Epub 2018 Feb 19.
Toxicology. 2018.
PMID: 29471073
Free PMC article.
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Impact of p53 function on the sulfotransferase-mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1-hydroxymethylpyrene in vitro.
Wohak LE, Monien B, Phillips DH, Arlt VM.
Wohak LE, et al.
Environ Mol Mutagen. 2019 Oct;60(8):752-758. doi: 10.1002/em.22299. Epub 2019 Jun 4.
Environ Mol Mutagen. 2019.
PMID: 31102418
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