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Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Parthasarathy S, Henry K, Pei H, Clayton J, Rempala M, Johns D, De Frutos O, Garcia P, Mateos C, Pleite S, Wang Y, Stout S, Condon B, Ashok S, Lu Z, Ehlhardt W, Raub T, Lai M, Geeganage S, Burkholder TP. Parthasarathy S, et al. Among authors: ashok s. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891. doi: 10.1016/j.bmcl.2018.03.092. Epub 2018 Apr 2. Bioorg Med Chem Lett. 2018. PMID: 29655979
The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
Zhao X, Allison D, Condon B, Zhang F, Gheyi T, Zhang A, Ashok S, Russell M, MacEwan I, Qian Y, Jamison JA, Luz JG. Zhao X, et al. Among authors: ashok s. J Med Chem. 2013 Feb 14;56(3):963-9. doi: 10.1021/jm301431y. Epub 2013 Jan 29. J Med Chem. 2013. PMID: 23311358
Structural context of disease-associated mutations and putative mechanism of autoinhibition revealed by X-ray crystallographic analysis of the EZH2-SET domain.
Antonysamy S, Condon B, Druzina Z, Bonanno JB, Gheyi T, Zhang F, MacEwan I, Zhang A, Ashok S, Rodgers L, Russell M, Gately Luz J. Antonysamy S, et al. Among authors: ashok s. PLoS One. 2013 Dec 19;8(12):e84147. doi: 10.1371/journal.pone.0084147. eCollection 2013. PLoS One. 2013. PMID: 24367637 Free PMC article.
Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition.
Zhao X, Allison D, Condon B, Zhang F, Gheyi T, Zhang A, Ashok S, Russell M, MacEwan I, Qian Y, Jamison JA, Luz JG. Zhao X, et al. Among authors: ashok s. J Med Chem. 2016 Mar 10;59(5):2267. doi: 10.1021/acs.jmedchem.6b00130. Epub 2016 Feb 16. J Med Chem. 2016. PMID: 26882000 No abstract available.
Indole fragments for the design of lead molecules against pancreatitis.
Dileep KV, Ashok S, Remya C, Dharmendra KY, Pérez-Sánchez H, Sadasivan C. Dileep KV, et al. Among authors: ashok s. J Biomol Struct Dyn. 2020 Jan;38(1):263-267. doi: 10.1080/07391102.2019.1567389. Epub 2019 Feb 19. J Biomol Struct Dyn. 2020. PMID: 30633717
107 results