Guan KL - Search Results

1

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells.

Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. Badur MG, et al. Among authors: guan kl. Cell Rep. 2018 Nov 6;25(6):1680. doi: 10.1016/j.celrep.2018.10.099. Cell Rep. 2018. PMID: 30404018 Free PMC article. No abstract available.

2

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.

Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. Badur MG, et al. Among authors: guan kl. Cell Rep. 2018 Oct 23;25(4):1018-1026.e4. doi: 10.1016/j.celrep.2018.09.074. Cell Rep. 2018. PMID: 30355481 Free PMC article.

3

R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis.

Ye D, Ma S, Xiong Y, Guan KL. Ye D, et al. Among authors: guan kl. Cancer Cell. 2013 Mar 18;23(3):274-6. doi: 10.1016/j.ccr.2013.03.005. Cancer Cell. 2013. PMID: 23518346 Free PMC article.

4

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.

Wang P, Wu J, Ma S, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan KL, Ye D, Xiong Y. Wang P, et al. Among authors: guan kl. Cell Rep. 2015 Dec 22;13(11):2353-2361. doi: 10.1016/j.celrep.2015.11.029. Epub 2015 Dec 10. Cell Rep. 2015. PMID: 26686626 Free PMC article.

5

Polycystic kidney disease: a Hippo connection.

Ma S, Guan KL. Ma S, et al. Among authors: guan kl. Genes Dev. 2018 Jun 1;32(11-12):737-739. doi: 10.1101/gad.316570.118. Genes Dev. 2018. PMID: 29921661 Free PMC article. Review.

6

STRIPAK integrates upstream signals to initiate the Hippo kinase cascade.

Chen R, Xie R, Meng Z, Ma S, Guan KL. Chen R, et al. Among authors: guan kl. Nat Cell Biol. 2019 Dec;21(12):1565-1577. doi: 10.1038/s41556-019-0426-y. Epub 2019 Dec 2. Nat Cell Biol. 2019. PMID: 31792377

7

Publisher Correction: STRIPAK integrates upstream signals to initiate the Hippo kinase cascade.

Chen R, Xie R, Meng Z, Ma S, Guan KL. Chen R, et al. Among authors: guan kl. Nat Cell Biol. 2020 Feb;22(2):257. doi: 10.1038/s41556-019-0460-9. Nat Cell Biol. 2020. PMID: 31896773

8

The Hippo Pathway: Biology and Pathophysiology.

Ma S, Meng Z, Chen R, Guan KL. Ma S, et al. Among authors: guan kl. Annu Rev Biochem. 2019 Jun 20;88:577-604. doi: 10.1146/annurev-biochem-013118-111829. Epub 2019 Dec 19. Annu Rev Biochem. 2019. PMID: 30566373 Review.

9

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.

Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan KL, Xiong Y. Wang Y, et al. Among authors: guan kl. Mol Cell. 2015 Feb 19;57(4):662-673. doi: 10.1016/j.molcel.2014.12.023. Epub 2015 Jan 15. Mol Cell. 2015. PMID: 25601757 Free PMC article.

10

D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.

Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan KL. Ma S, et al. Among authors: guan kl. Oncotarget. 2015 Apr 20;6(11):8606-20. doi: 10.18632/oncotarget.3330. Oncotarget. 2015. PMID: 25825982 Free PMC article.

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