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Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK. McWilliams TG, et al. Among authors: ganley ig. Open Biol. 2018 Nov 7;8(11):180108. doi: 10.1098/rsob.180108. Open Biol. 2018. PMID: 30404819 Free PMC article.
Loss of iron triggers PINK1/Parkin-independent mitophagy.
Allen GF, Toth R, James J, Ganley IG. Allen GF, et al. Among authors: ganley ig. EMBO Rep. 2013 Dec;14(12):1127-35. doi: 10.1038/embor.2013.168. Epub 2013 Nov 1. EMBO Rep. 2013. PMID: 24176932 Free PMC article.
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR. Bago R, et al. Among authors: ganley ig. Biochem J. 2014 Nov 1;463(3):413-27. doi: 10.1042/BJ20140889. Biochem J. 2014. PMID: 25177796 Free PMC article.
mito-QC illuminates mitophagy and mitochondrial architecture in vivo.
McWilliams TG, Prescott AR, Allen GF, Tamjar J, Munson MJ, Thomson C, Muqit MM, Ganley IG. McWilliams TG, et al. Among authors: ganley ig. J Cell Biol. 2016 Aug 1;214(3):333-45. doi: 10.1083/jcb.201603039. Epub 2016 Jul 25. J Cell Biol. 2016. PMID: 27458135 Free PMC article.
76 results