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Prevention of radiation-induced bystander effects by agents that inactivate cell-free chromatin released from irradiated dying cells.
Kirolikar S, Prasannan P, Raghuram GV, Pancholi N, Saha T, Tidke P, Chaudhari P, Shaikh A, Rane B, Pandey R, Wani H, Khare NK, Siddiqui S, D'souza J, Prasad R, Shinde S, Parab S, Nair NK, Pal K, Mittra I. Kirolikar S, et al. Among authors: mittra i. Cell Death Dis. 2018 Nov 15;9(12):1142. doi: 10.1038/s41419-018-1181-x. Cell Death Dis. 2018. PMID: 30442925 Free PMC article.
Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation.
Mittra I, Samant U, Sharma S, Raghuram GV, Saha T, Tidke P, Pancholi N, Gupta D, Prasannan P, Gaikwad A, Gardi N, Chaubal R, Upadhyay P, Pal K, Rane B, Shaikh A, Salunkhe S, Dutt S, Mishra PK, Khare NK, Nair NK, Dutt A. Mittra I, et al. Cell Death Discov. 2017 May 29;3:17015. doi: 10.1038/cddiscovery.2017.15. eCollection 2017. Cell Death Discov. 2017. PMID: 28580170 Free PMC article.
Is inflammation a direct response to dsDNA breaks?
Chaudhary S, Raghuram GV, Mittra I. Chaudhary S, et al. Among authors: mittra i. Mutat Res. 2018 Mar;808:48-52. doi: 10.1016/j.mrfmmm.2018.02.002. Epub 2018 Feb 22. Mutat Res. 2018. PMID: 29518635
118 results