Shorter J - Search Results

1

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R. Vogler TO, et al. Among authors: shorter j. Nature. 2018 Nov;563(7732):508-513. doi: 10.1038/s41586-018-0665-2. Epub 2018 Oct 31. Nature. 2018. PMID: 30464263 Free PMC article.

2

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.

Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD. Johnson BS, et al. Among authors: shorter j. J Biol Chem. 2009 Jul 24;284(30):20329-39. doi: 10.1074/jbc.M109.010264. Epub 2009 May 22. J Biol Chem. 2009. PMID: 19465477 Free PMC article.

3

RNA-binding proteins with prion-like domains in ALS and FTLD-U.

Gitler AD, Shorter J. Gitler AD, et al. Among authors: shorter j. Prion. 2011 Jul-Sep;5(3):179-87. doi: 10.4161/pri.5.3.17230. Epub 2011 Jul 1. Prion. 2011. PMID: 21847013 Free PMC article. Review.

4

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.

Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV Jr, Gitler AD. Armakola M, et al. Among authors: shorter j. Nat Genet. 2012 Dec;44(12):1302-9. doi: 10.1038/ng.2434. Epub 2012 Oct 28. Nat Genet. 2012. PMID: 23104007 Free PMC article.

5

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP. Kim HJ, et al. Among authors: shorter j. Nature. 2013 Mar 28;495(7442):467-73. doi: 10.1038/nature11922. Epub 2013 Mar 3. Nature. 2013. PMID: 23455423 Free PMC article.

6

Stress granules as crucibles of ALS pathogenesis.

Li YR, King OD, Shorter J, Gitler AD. Li YR, et al. Among authors: shorter j. J Cell Biol. 2013 Apr 29;201(3):361-72. doi: 10.1083/jcb.201302044. J Cell Biol. 2013. PMID: 23629963 Free PMC article. Review.

7

Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly.

Shorter J, Taylor JP. Shorter J, et al. Rare Dis. 2013 May 29;1:e25200. doi: 10.4161/rdis.25200. eCollection 2013. Rare Dis. 2013. PMID: 25002999 Free PMC article.

8

Membraneless organelles: Phasing in and out.

Shorter J. Shorter J. Nat Chem. 2016 May 24;8(6):528-30. doi: 10.1038/nchem.2534. Nat Chem. 2016. PMID: 27219695 No abstract available.

9

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.

Guo L, Shorter J. Guo L, et al. Among authors: shorter j. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a024554. doi: 10.1101/cshperspect.a024554. Cold Spring Harb Perspect Med. 2017. PMID: 27920024 Free PMC article. Review.

10

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.

Yasuda K, Clatterbuck-Soper SF, Jackrel ME, Shorter J, Mili S. Yasuda K, et al. Among authors: shorter j. J Cell Biol. 2017 Apr 3;216(4):1015-1034. doi: 10.1083/jcb.201608022. Epub 2017 Mar 15. J Cell Biol. 2017. PMID: 28298410 Free PMC article.

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