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APOE genotype affects metabolic and Alzheimer-related outcomes induced by Western diet in female EFAD mice.
Christensen A, Pike CJ. Christensen A, et al. FASEB J. 2019 Mar;33(3):4054-4066. doi: 10.1096/fj.201801756R. Epub 2018 Dec 3. FASEB J. 2019. PMID: 30509127 Free PMC article.
To investigate this issue, we studied the effects of Western diet (WD) on female EFAD mice, a transgenic mouse model of AD that includes human APOE alleles epsilon3 (E3FAD) and epsilon4 (E4FAD). ...Understanding how AD-promoting effects of obesity are modulated by genetic …
To investigate this issue, we studied the effects of Western diet (WD) on female EFAD mice, a transgenic mouse model of AD that inclu …
The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice.
Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, Charidimou A, Wahlund LO, Wiberg MK, Shams S, Chiang GC; Alzheimer's Disease Neuroimaging Initiative; Finch CE. Cacciottolo M, et al. Among authors: christensen a. Neurobiol Aging. 2016 Jan;37:47-57. doi: 10.1016/j.neurobiolaging.2015.10.010. Epub 2015 Oct 19. Neurobiol Aging. 2016. PMID: 26686669 Free PMC article.
Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.
Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. Yen K, et al. Among authors: christensen a. Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. Sci Rep. 2018. PMID: 30242290 Free PMC article.
1,719 results