Tsimikas S - Search Results

1

Integrated Assessment of the Clinical Performance of GalNAc₃-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.

Crooke ST, Baker BF, Xia S, Yu RZ, Viney NJ, Wang Y, Tsimikas S, Geary RS. Crooke ST, et al. Among authors: tsimikas s. Nucleic Acid Ther. 2019 Feb;29(1):16-32. doi: 10.1089/nat.2018.0753. Epub 2018 Dec 20. Nucleic Acid Ther. 2019. PMID: 30570431 Free PMC article. Clinical Trial.

2

Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.

Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum JL. Tsimikas S, et al. Lancet. 2015 Oct 10;386(10002):1472-83. doi: 10.1016/S0140-6736(15)61252-1. Epub 2015 Jul 22. Lancet. 2015. PMID: 26210642 Clinical Trial.

3

Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.

Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ, Marcovina SM, Hughes SG, Graham MJ, Crooke RM, Crooke ST, Witztum JL, Stroes ES, Tsimikas S. Viney NJ, et al. Among authors: tsimikas s. Lancet. 2016 Nov 5;388(10057):2239-2253. doi: 10.1016/S0140-6736(16)31009-1. Epub 2016 Sep 21. Lancet. 2016. PMID: 27665230 Clinical Trial.

4

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.

Graham MJ, Lee RG, Brandt TA, Tai LJ, Fu W, Peralta R, Yu R, Hurh E, Paz E, McEvoy BW, Baker BF, Pham NC, Digenio A, Hughes SG, Geary RS, Witztum JL, Crooke RM, Tsimikas S. Graham MJ, et al. Among authors: tsimikas s. N Engl J Med. 2017 Jul 20;377(3):222-232. doi: 10.1056/NEJMoa1701329. Epub 2017 May 24. N Engl J Med. 2017. PMID: 28538111 Free article. Clinical Trial.

5

Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)_Rx and IONIS-APO(a)-L_Rx antisense oligonucleotide clinical trials.

Marcovina SM, Viney NJ, Hughes SG, Xia S, Witztum JL, Tsimikas S. Marcovina SM, et al. Among authors: tsimikas s. J Clin Lipidol. 2018 Jan-Feb;12(1):122-129.e2. doi: 10.1016/j.jacl.2017.10.024. Epub 2017 Nov 2. J Clin Lipidol. 2018. PMID: 29174389 Clinical Trial.

6

The Effects of 2'-O-Methoxyethyl Oligonucleotides on Renal Function in Humans.

Crooke ST, Baker BF, Pham NC, Hughes SG, Kwoh TJ, Cai D, Tsimikas S, Geary RS, Bhanot S. Crooke ST, et al. Among authors: tsimikas s. Nucleic Acid Ther. 2018 Feb;28(1):10-22. doi: 10.1089/nat.2017.0693. Epub 2017 Nov 29. Nucleic Acid Ther. 2018. PMID: 29185862 Free PMC article.

7

Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide.

Viney NJ, Yeang C, Yang X, Xia S, Witztum JL, Tsimikas S. Viney NJ, et al. Among authors: tsimikas s. J Clin Lipidol. 2018 May-Jun;12(3):702-710. doi: 10.1016/j.jacl.2018.02.014. Epub 2018 Mar 1. J Clin Lipidol. 2018. PMID: 29574075 Clinical Trial.

8

Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size.

Tsimikas S, Fazio S, Viney NJ, Xia S, Witztum JL, Marcovina SM. Tsimikas S, et al. J Clin Lipidol. 2018 Sep-Oct;12(5):1313-1323. doi: 10.1016/j.jacl.2018.07.003. Epub 2018 Jul 20. J Clin Lipidol. 2018. PMID: 30100157

9

N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels.

Alexander VJ, Xia S, Hurh E, Hughes SG, O'Dea L, Geary RS, Witztum JL, Tsimikas S. Alexander VJ, et al. Among authors: tsimikas s. Eur Heart J. 2019 Sep 1;40(33):2785-2796. doi: 10.1093/eurheartj/ehz209. Eur Heart J. 2019. PMID: 31329855 Free PMC article. Clinical Trial.

10

Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome.

Witztum JL, Gaudet D, Freedman SD, Alexander VJ, Digenio A, Williams KR, Yang Q, Hughes SG, Geary RS, Arca M, Stroes ESG, Bergeron J, Soran H, Civeira F, Hemphill L, Tsimikas S, Blom DJ, O'Dea L, Bruckert E. Witztum JL, et al. Among authors: tsimikas s. N Engl J Med. 2019 Aug 8;381(6):531-542. doi: 10.1056/NEJMoa1715944. N Engl J Med. 2019. PMID: 31390500 Clinical Trial.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

368 results

Search Page