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Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma.
El-Hachem N, Leclercq M, Susaeta Ruiz M, Vanleyssem R, Shostak K, Körner PR, Capron C, Martin-Morales L, Roncarati P, Lavergne A, Blomme A, Turchetto S, Goffin E, Thandapani P, Tarassov I, Nguyen L, Pirotte B, Chariot A, Marine JC, Herfs M, Rapino F, Agami R, Close P. El-Hachem N, et al. Nat Cell Biol. 2024 Jun 7. doi: 10.1038/s41556-024-01439-2. Online ahead of print. Nat Cell Biol. 2024. PMID: 38849541
A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses.
Gonçalves MP, Farah R, Bikorimana JP, Abusarah J, El-Hachem N, Saad W, Talbot S, Stanga D, Beaudoin S, Plouffe S, Rafei M. Gonçalves MP, et al. Among authors: el hachem n. iScience. 2024 Feb 17;27(3):109248. doi: 10.1016/j.isci.2024.109248. eCollection 2024 Mar 15. iScience. 2024. PMID: 38433914 Free PMC article.
CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S. Gress V, et al. Among authors: el hachem n. Blood Adv. 2024 Jan 9;8(1):112-129. doi: 10.1182/bloodadvances.2022008899. Blood Adv. 2024. PMID: 37729615 Free PMC article.
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.
Largeot A, Klapp V, Viry E, Gonder S, Fernandez Botana I, Blomme A, Benzarti M, Pierson S, Duculty C, Marttila P, Wierz M, Gargiulo E, Pagano G, An N, El Hachem N, Perez Hernandez D, Chakraborty S, Ysebaert L, François JH, Cortez Clemente S, Berchem G, Efremov DG, Dittmar G, Szpakowska M, Chevigné A, Nazarov PV, Helleday T, Close P, Meiser J, Stamatopoulos B, Désaubry L, Paggetti J, Moussay E. Largeot A, et al. Among authors: el hachem n. Blood. 2023 Jun 29;141(26):3166-3183. doi: 10.1182/blood.2022017839. Blood. 2023. PMID: 37084385 Free PMC article.
Acute inflammatory response via neutrophil activation protects against the development of chronic pain.
Parisien M, Lima LV, Dagostino C, El-Hachem N, Drury GL, Grant AV, Huising J, Verma V, Meloto CB, Silva JR, Dutra GGS, Markova T, Dang H, Tessier PA, Slade GD, Nackley AG, Ghasemlou N, Mogil JS, Allegri M, Diatchenko L. Parisien M, et al. Among authors: el hachem n. Sci Transl Med. 2022 May 11;14(644):eabj9954. doi: 10.1126/scitranslmed.abj9954. Epub 2022 May 11. Sci Transl Med. 2022. PMID: 35544595 Free PMC article.
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