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Three-dimensional pancreas organogenesis models.
Grapin-Botton A. Grapin-Botton A. Diabetes Obes Metab. 2016 Sep;18 Suppl 1(Suppl 1):33-40. doi: 10.1111/dom.12720. Diabetes Obes Metab. 2016. PMID: 27615129 Free PMC article. Review.
The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.
Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T. Tsonkova VG, et al. Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19. Mol Metab. 2018. PMID: 29307512 Free PMC article.
Long-term feeder-free culture of human pancreatic progenitors on fibronectin or matrix-free polymer potentiates β cell differentiation.
Nakamura A, Wong YF, Venturato A, Michaut M, Venkateswaran S, Santra M, Gonçalves C, Larsen M, Leuschner M, Kim YH, Brickman J, Bradley M, Grapin-Botton A. Nakamura A, et al. Among authors: grapin botton a. Stem Cell Reports. 2022 May 10;17(5):1215-1228. doi: 10.1016/j.stemcr.2022.03.013. Epub 2022 Apr 21. Stem Cell Reports. 2022. PMID: 35452596 Free PMC article.
Pairing-up SOX to kick-start beta cell genesis.
Grapin-Botton A, Seymour PA, Gradwohl G. Grapin-Botton A, et al. Diabetologia. 2015 May;58(5):859-61. doi: 10.1007/s00125-015-3539-2. Epub 2015 Mar 4. Diabetologia. 2015. PMID: 25733380
84 results