Simpson TJ - Search Results

1

Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586.

Connolly JA, Wilson A, Macioszek M, Song Z, Wang L, Mohammad HH, Yadav M, di Martino M, Miller CE, Hothersall J, Haines AS, Stephens ER, Crump MP, Willis CL, Simpson TJ, Winn PJ, Thomas CM. Connolly JA, et al. Among authors: simpson tj. Sci Rep. 2019 Feb 7;9(1):1542. doi: 10.1038/s41598-018-38038-9. Sci Rep. 2019. PMID: 30733464 Free PMC article.

2

Conserved secondary structure in the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) and the fatty acid synthase acyl carrier protein from Escherichia coli.

Crump MP, Crosby J, Dempsey CE, Murray M, Hopwood DA, Simpson TJ. Crump MP, et al. Among authors: simpson tj. FEBS Lett. 1996 Aug 12;391(3):302-6. doi: 10.1016/0014-5793(96)00756-9. FEBS Lett. 1996. PMID: 8764994 Free article.

3

Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2).

Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ. Crump MP, et al. Among authors: simpson tj. Biochemistry. 1997 May 20;36(20):6000-8. doi: 10.1021/bi970006+. Biochemistry. 1997. PMID: 9166770

4

Acylation of Streptomyces type II polyketide synthase acyl carrier proteins.

Crosby J, Byrom KJ, Hitchman TS, Cox RJ, Crump MP, Findlow IS, Bibb MJ, Simpson TJ. Crosby J, et al. Among authors: simpson tj. FEBS Lett. 1998 Aug 14;433(1-2):132-8. doi: 10.1016/s0014-5793(98)00840-0. FEBS Lett. 1998. PMID: 9738947 Free article.

5

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

El-Sayed AK, Hothersall J, Cooper SM, Stephens E, Simpson TJ, Thomas CM. El-Sayed AK, et al. Among authors: simpson tj. Chem Biol. 2003 May;10(5):419-30. doi: 10.1016/s1074-5521(03)00091-7. Chem Biol. 2003. PMID: 12770824

6

Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus.

Findlow SC, Winsor C, Simpson TJ, Crosby J, Crump MP. Findlow SC, et al. Among authors: simpson tj. Biochemistry. 2003 Jul 22;42(28):8423-33. doi: 10.1021/bi0342259. Biochemistry. 2003. PMID: 12859187

7

The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs.

Reed MA, Schweizer M, Szafranska AE, Arthur C, Nicholson TP, Cox RJ, Crosby J, Crump MP, Simpson TJ. Reed MA, et al. Among authors: simpson tj. Org Biomol Chem. 2003 Feb 7;1(3):463-71. doi: 10.1039/b208941f. Org Biomol Chem. 2003. PMID: 12926246

8

Synthesis and incorporation of the first polyketide synthase free intermediate in monocerin biosynthesis.

Axford LC, Simpson TJ, Willis CL. Axford LC, et al. Among authors: simpson tj. Angew Chem Int Ed Engl. 2004 Jan 30;43(6):727-30. doi: 10.1002/anie.200352652. Angew Chem Int Ed Engl. 2004. PMID: 14755704 No abstract available.

9

Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.

Teartasin W, Limpkin C, Glod F, Spencer J, Cox RJ, Simpson TJ, Crosby J, Crump MP, Hadfield AT. Teartasin W, et al. Among authors: simpson tj. Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1137-8. doi: 10.1107/S0907444904007905. Epub 2004 May 21. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 15159580

10

The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.

Hadfield AT, Limpkin C, Teartasin W, Simpson TJ, Crosby J, Crump MP. Hadfield AT, et al. Among authors: simpson tj. Structure. 2004 Oct;12(10):1865-75. doi: 10.1016/j.str.2004.08.002. Structure. 2004. PMID: 15458634 Free article.

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