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Predictable and precise template-free CRISPR editing of pathogenic variants.
Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI. Shen MW, et al. Among authors: liu dr. Nature. 2018 Nov;563(7733):646-651. doi: 10.1038/s41586-018-0686-x. Epub 2018 Nov 7. Nature. 2018. PMID: 30405244 Free PMC article.
CRISPResso2 provides accurate and rapid genome editing sequence analysis.
Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L. Clement K, et al. Among authors: liu dr. Nat Biotechnol. 2019 Mar;37(3):224-226. doi: 10.1038/s41587-019-0032-3. Nat Biotechnol. 2019. PMID: 30809026 Free PMC article. No abstract available.
Continuous evolution of SpCas9 variants compatible with non-G PAMs.
Miller SM, Wang T, Randolph PB, Arbab M, Shen MW, Huang TP, Matuszek Z, Newby GA, Rees HA, Liu DR. Miller SM, et al. Among authors: liu dr. Nat Biotechnol. 2020 Apr;38(4):471-481. doi: 10.1038/s41587-020-0412-8. Epub 2020 Feb 10. Nat Biotechnol. 2020. PMID: 32042170 Free PMC article.
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR. Koblan LW, et al. Among authors: liu dr. Nat Biotechnol. 2021 Nov;39(11):1414-1425. doi: 10.1038/s41587-021-00938-z. Epub 2021 Jun 28. Nat Biotechnol. 2021. PMID: 34183861 Free PMC article.
381 results