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Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, Osborne LC, Hepworth MR, Tran SV, Rodewald HR, Shah H, Cross JR, Diamond JM, Cantu E, Christie JD, Pearce EL, Artis D. Monticelli LA, et al. Among authors: flamar al. Nat Immunol. 2016 Jun;17(6):656-65. doi: 10.1038/ni.3421. Epub 2016 Apr 4. Nat Immunol. 2016. PMID: 27043409 Free PMC article.
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.
Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D. Klose CSN, et al. Among authors: flamar al. Nature. 2017 Sep 14;549(7671):282-286. doi: 10.1038/nature23676. Epub 2017 Sep 6. Nature. 2017. PMID: 28869965 Free PMC article.
Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.
Flamar AL, Klose CSN, Moeller JB, Mahlakõiv T, Bessman NJ, Zhang W, Moriyama S, Stokic-Trtica V, Rankin LC, Putzel GG, Rodewald HR, He Z, Chen L, Lira SA, Karsenty G, Artis D. Flamar AL, et al. Immunity. 2020 Apr 14;52(4):606-619.e6. doi: 10.1016/j.immuni.2020.02.009. Epub 2020 Mar 10. Immunity. 2020. PMID: 32160524 Free PMC article.
Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.
Moeller JB, Leonardi I, Schlosser A, Flamar AL, Bessman NJ, Putzel GG, Thomsen T, Hammond M, Jepsen CS, Skjødt K, Füchtbauer EM, Farber DL, Sorensen GL, Iliev ID, Holmskov U, Artis D. Moeller JB, et al. Among authors: flamar al. J Exp Med. 2019 Dec 2;216(12):2689-2700. doi: 10.1084/jem.20182244. Epub 2019 Oct 10. J Exp Med. 2019. PMID: 31601676 Free PMC article.
ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.
Campbell L, Hepworth MR, Whittingham-Dowd J, Thompson S, Bancroft AJ, Hayes KS, Shaw TN, Dickey BF, Flamar AL, Artis D, Schwartz DA, Evans CM, Roberts IS, Thornton DJ, Grencis RK. Campbell L, et al. Among authors: flamar al. J Exp Med. 2019 Dec 2;216(12):2714-2723. doi: 10.1084/jem.20180610. Epub 2019 Oct 3. J Exp Med. 2019. PMID: 31582416 Free PMC article.
Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer.
Goc J, Lv M, Bessman NJ, Flamar AL, Sahota S, Suzuki H, Teng F, Putzel GG; JRI Live Cell Bank; Eberl G, Withers DR, Arthur JC, Shah MA, Sonnenberg GF. Goc J, et al. Among authors: flamar al. Cell. 2021 Sep 16;184(19):5015-5030.e16. doi: 10.1016/j.cell.2021.07.029. Epub 2021 Aug 17. Cell. 2021. PMID: 34407392 Free PMC article.
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