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A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ. Chefetz I, et al. Among authors: yang k. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032. Cell Rep. 2019. PMID: 30865894 Free PMC article.
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Huddle BC, Grimley E, Buchman CD, Chtcherbinine M, Debnath B, Mehta P, Yang K, Morgan CA, Li S, Felton J, Sun D, Mehta G, Neamati N, Buckanovich RJ, Hurley TD, Larsen SD. Huddle BC, et al. Among authors: yang k. J Med Chem. 2018 Oct 11;61(19):8754-8773. doi: 10.1021/acs.jmedchem.8b00930. Epub 2018 Sep 28. J Med Chem. 2018. PMID: 30221940 Free PMC article.
Metformin targets ovarian cancer stem cells in vitro and in vivo.
Shank JJ, Yang K, Ghannam J, Cabrera L, Johnston CJ, Reynolds RK, Buckanovich RJ. Shank JJ, et al. Among authors: yang k. Gynecol Oncol. 2012 Nov;127(2):390-7. doi: 10.1016/j.ygyno.2012.07.115. Epub 2012 Aug 2. Gynecol Oncol. 2012. PMID: 22864111 Free PMC article.
Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer.
Brown JR, Chan DK, Shank JJ, Griffith KA, Fan H, Szulawski R, Yang K, Reynolds RK, Johnston C, McLean K, Uppal S, Liu JR, Cabrera L, Taylor SE, Orr BC, Modugno F, Mehta P, Bregenzer M, Mehta G, Shen H, Coffman LG, Buckanovich RJ. Brown JR, et al. Among authors: yang k. JCI Insight. 2020 Jun 4;5(11):e133247. doi: 10.1172/jci.insight.133247. JCI Insight. 2020. PMID: 32369446 Free PMC article. Clinical Trial.
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