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MuSK myasthenia gravis monoclonal antibodies: Valency dictates pathogenicity.
Huijbers MG, Vergoossen DL, Fillié-Grijpma YE, van Es IE, Koning MT, Slot LM, Veelken H, Plomp JJ, van der Maarel SM, Verschuuren JJ. Huijbers MG, et al. Among authors: slot lm. Neurol Neuroimmunol Neuroinflamm. 2019 Feb 21;6(3):e547. doi: 10.1212/NXI.0000000000000547. eCollection 2019 May. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 30882021 Free PMC article.
B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation.
Vergroesen RD, Slot LM, Hafkenscheid L, Koning MT, van der Voort EIH, Grooff CA, Zervakis G, Veelken H, Huizinga TWJ, Rispens T, Scherer HU, Toes REM. Vergroesen RD, et al. Among authors: slot lm. Ann Rheum Dis. 2018 Jun;77(6):956-958. doi: 10.1136/annrheumdis-2017-212052. Epub 2017 Aug 23. Ann Rheum Dis. 2018. PMID: 28835463 No abstract available.
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.
Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC, Kampstra A, Levarht E, Drijfhout JW, Bang H, Bonger KM, Janssen G, van Veelen PA, Huizinga T, Scherer HU, Reth M, Toes R. Kissel T, et al. Among authors: slot lm. Ann Rheum Dis. 2020 Apr;79(4):472-480. doi: 10.1136/annrheumdis-2019-216499. Epub 2020 Feb 10. Ann Rheum Dis. 2020. PMID: 32041746
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load.
Reijm S, Kissel T, Stoeken-Rijsbergen G, Slot LM, Wortel CM, van Dooren HJ, Levarht NEW, Kampstra ASB, Derksen VFAM, Heer PO, Bang H, Drijfhout JW, Trouw LA, Huizinga TWJ, Rispens T, Scherer HU, Toes REM. Reijm S, et al. Among authors: slot lm. Arthritis Res Ther. 2021 Sep 3;23(1):230. doi: 10.1186/s13075-021-02609-5. Arthritis Res Ther. 2021. PMID: 34479638 Free PMC article.
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.
He Y, Ge C, Moreno-Giró À, Xu B, Beusch CM, Sandor K, Su J, Cheng L, Lönnblom E, Lundqvist C, Slot LM, Tong D, Urbonaviciute V, Liang B, Li T, Lahore GF, Aoun M, Malmström V, Rispens T, Ernfors P, Svensson CI, Scherer HU, Toes REM, Gjertsson I, Ekwall O, Zubarev RA, Holmdahl R. He Y, et al. Among authors: slot lm. Nat Commun. 2023 Feb 8;14(1):691. doi: 10.1038/s41467-023-36257-x. Nat Commun. 2023. PMID: 36754962 Free PMC article.
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