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A targetable 'rogue' neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS.
Herrera VLM, Walkey AJ, Nguyen MQ, Gromisch CM, Mosaddhegi JZ, Gromisch MS, Jundi B, Lukassen S, Carstensen S, Denis R, Belkina AC, Baron RM, Pinilla-Vera M, Mueller M, Kimberly WT, Goldstein JN, Lehmann I, Shih AR, Eils R, Levy BD, Ruiz-Opazo N. Herrera VLM, et al. Among authors: gromisch cm. Sci Rep. 2022 Apr 4;12(1):5583. doi: 10.1038/s41598-022-09343-1. Sci Rep. 2022. PMID: 35379853 Free PMC article.
Increased Neutrophil-Subset Associated With Severity/Mortality In ARDS And COVID19-ARDS Expresses The Dual Endothelin-1/VEGFsignal-Peptide Receptor (DEspR): An Actionable Therapeutic Target.
Herrera VLM, Walkey AJ, Nguyen MQ, Gromisch CM, Mosaddhegi JZ, Gromisch MS, Jundi B, Lukassen S, Carstensen S, Denis R, Belkina AC, Baron RM, Pinilla-Vera M, Muller M, Kimberly WT, Goldstein JN, Lehmann I, Shih AR, Ells R, Levy BD, Rulz-Opazo N. Herrera VLM, et al. Among authors: gromisch cm. Res Sq [Preprint]. 2021 Sep 13:rs.3.rs-846250. doi: 10.21203/rs.3.rs-846250/v1. Res Sq. 2021. PMID: 34545358 Free PMC article. Preprint.